Project Grant K23HL175122
- The federal Project Grant award by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $534,761 to the University of California, Los Angeles (UCLA) to develop "Magnetoelastic Vascular Grafts" (MVGs). The MVGs are a transformative platform technology that can wirelessly and continuously monitor blood flow and detect stenosis (narrowing) in vascular grafts, a common issue affecting nearly 40% of grafts within 2 years of implantation. The...
- The $784,203 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is supporting the development and testing of a small, durable, and hemocompatible centrifugal blood pump for use in children aged 1-11 years (weighing approximately 10-35 kg) with heart failure. The immediate goal is to test and refine the "PSU Child VAD" (ventricular assist device) prototype through a series of 30-day in-vivo studies to validate the design...
- The federal Project Grant award titled "OVERCOMING BARRIERS TO EXPERT-INFORMED CARE FOR VASCULAR ANOMALIES THROUGH A WEB-BASED PLATFORM: THE VACCESS PROGRAM" was provided by the Defense Health Agency, which administers the Military Medical Research and Development program (CFDA 12.420). The $418,965 award, effective from March 1, 2025 to February 28, 2027, will fund the development and implementation of a web-based platform to improve access to expert-informed care for individuals with...
- This Project Grant award of $618,450.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to identify key regulators of vascular homeostasis and understand how they maintain normal vascular function. The principal investigators at the Medical College of Wisconsin are focusing on understanding the role of the RNA-binding protein PABPC1 in suppressing endothelial cell activation and inflammation to prevent the loss of vascular...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,092,000 to The Medical College of Wisconsin, Inc. to conduct research on the intersection of the PPARG-RHOBTB1-CULLIN-3 pathway and the renin-angiotensin system and their impact on blood pressure, vascular function, and arterial stiffness. The research aims to advance understanding of the regulatory circuits governing vascular function and arterial structure,...
- This $1,332,404 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research into the role of basolateral endothelial cilia in promoting vascular stability in the brain. The awardee, The Medical College of Wisconsin, Inc., will investigate the hypothesis that basolateral endothelial cilia facilitate cell-cell communication with pericytes to regulate vascular stability through signaling pathways involving PDGF-BB, heparan...
- This Project Grant award from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), provides $464,229 to Limax Biosciences Inc. to advance the development of their HEMOMAX biodegradable hydrogel sealant for use in vascular surgery. The key objectives are to: (1) conduct comprehensive bench performance testing, including sterilization validation and endotoxin assessment, and (2) evaluate the safety and efficacy of HEMOMAX in a...
- This $321,679 Project Grant, awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports the development and testing of an expandable pediatric pulmonary heart valve device. The research aims to create a valve that can grow larger with the patient to address the challenge of multiple open-heart surgeries required for infants and children with severe heart valve defects. The key research activities include optimizing the...
- This federal Cooperative Agreement award of $968,769 was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research (CFDA 93.837) program. The award, titled "ARDVARC-ADVANCING RARE DISORDERS: VASCULAR MALFORMATION RESEARCH NETWORK WITH CANVAS", supports a research network focused on advancing clinical trial readiness for rare, complex vascular malformation disorders. The research network, led by the Children's Hospital of Philadelphia (CHOP),...
- This federal Project Grant, awarded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), supports research to assess the timing and risk of developing Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) and sepsis in children following congenital heart defect (CHD) surgery. The $271,938 award to Vanderbilt University Medical Center (VUMC) will fund a deeper analysis of institutional databases to understand how this syndrome...
The federal Project Grant award of $155,321 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) is supporting the development and testing of a novel, user and patient-centered Vascular Access Pathway (VAP) for the initial delivery of vascular access care in hospitalized children. The primary objectives are to: (1) co-design the VAP for the initial delivery of vascular access care in hospitalized children; and (2) test the VAP in a single-site adaptive pragmatic clinical trial. The award recipient, The Medical College of Wisconsin, Inc., is an experienced federal grantee and contractor focused on advancing medical research and services across various government agencies. The project aims to improve the effectiveness, safety, and cost-efficiency of vascular access care delivery for the over 4 million U.S. hospitalized children who require vascular access annually.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $155.3k | 7/30/25 |