This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $154,796 to Vanderbilt University Medical Center to utilize non-invasive neuroimaging methods to investigate cerebral oxygen utilization in adults with sickle cell disease (SCD). The research aims to: 1) assess how treatment-induced increases in hemoglobin levels impact cerebral blood flow and arterial-to-venous transit times in SCD...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $637,526 to Duke University to conduct research on the role of sickle red blood cells (RBCs) in activating neutrophils and promoting vaso-occlusion in sickle cell disease (SCD). The key objectives of the research are to: 1) delineate the characteristics of sickle RBCs that contribute to neutrophil activation, 2) examine the...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $942,492 to Rush University Medical Center to conduct research on the association between silent brain infarcts (SBIs) and cognitive outcomes in survivors of spontaneous intracerebral hemorrhage (SICH). The key objectives are to determine if SBIs in SICH patients are linked to lower...
This Project Grant award, valued at $607,535, was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports research to investigate the effects of the breakdown product hemin on the pulmonary endothelium and its contribution to the pulmonary complications of sickle cell disease, including acute chest syndrome and pulmonary hypertension. The research aims to evaluate the specific effects of...
This Project Grant award in the amount of $710,899.00 was provided by the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), to The Washington University in St. Louis. The goal of this research project is to delineate the short and long-term neurocognitive impact of late-childhood iron deficiency anemia (IDA) in young females. Specifically, the project will evaluate cognitive function and brain structure/connectivity...
The National Institute on Aging (NIA) awarded a $471,885 Project Grant (CFDA 93.866 - Aging Research) to Oregon Health & Science University (OHSU) from June 1, 2025 to May 31, 2027. The project aims to investigate the mechanisms underlying brain vascular endothelial cell (BVEC) disruption following vascular brain injury, which can contribute to vascular cognitive impairment and dementia (VCID). Specifically, the project will test hypotheses related to how the glycosaminoglycan hyaluronan and...
This Project Grant award of $4,361,625 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a "VCID Center Without Walls for Understanding and Leveraging Small Vessel Cerebrovascular Disease Mechanisms in ADRD" at Washington University. The project aims to leverage advanced multi-omics and transcriptomic technologies to investigate the complex mechanisms underlying cerebral small vessel disease (CSVD) and its vascular contributions to dementia (VCID). Key...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the Cardiovascular Diseases Research federal grant program (CFDA 93.837), aims to evaluate methods for improving the homing and engraftment efficiency of CD34+ cells from sickle cell disease (SCD) patients. The $128,100 award to the New York Blood Center, Inc. will support research to determine if co-infusing the CD34+ cells with their flow-through accessory cells, normally discarded after CD34+ cell...
This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,332,404 to The Medical College of Wisconsin, Inc. to investigate the role of basolateral endothelial cilia in promoting vascular stability in the brain. The research aims to evaluate the localization of platelet-derived growth factor-BB (PDGF-BB) in the context of the extracellular matrix and basolateral endothelial cilia, investigate the role of...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $137,219 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to the University of Illinois in Chicago. The goal of this 5-year grant is to develop the skills of Dr. Santosh L. Saraf, a mid-career hematologist and physician-scientist, to mentor the next generation of junior investigators focused on sickle cell disease (SCD)-related research. The research aims to investigate genetic factors and the role of complement...
This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $195,846 to Washington University to investigate the role of blood-brain barrier disruption on ischemic brain injury and cognitive impairment in sickle cell disease (SCD). The key objectives are to: 1) assess blood-brain barrier permeability in SCD patients compared to healthy controls, 2) examine thromboinflammatory pathways associated with blood-brain barrier dysfunction, and 3) determine if baseline blood-brain barrier permeability can predict progression of ischemic brain injury and cognitive decline over a 30-month follow-up period. This research aims to fill knowledge gaps on the underlying mechanisms of cerebral microvasculopathy and cognitive consequences in SCD, which could guide development of future neuroprotective treatment strategies. The award period runs from August 1, 2025 to April 30, 2030.