Project Grant K23HD119673
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $179,475 to The Children's Hospital of Philadelphia (CHOP) to conduct research on pediatric sepsis. The key objectives of the project are to define and validate a molecular subphenotyping model that can predict the severity of sepsis in children, and to test the reversibility of immune dysregulation through targeting...
- This federal Project Grant award, provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research led by Dr. Carolyn McGann of the Children's Hospital of Philadelphia (CHOP) to define transmission pathways for sepsis-causing pathogens in low-resource settings using microbiome methods and spatial epidemiology. The $155,185 award, effective from...
- This $697,256 project grant awarded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to identify distinct subphenotypes and endotypes in children with sepsis-induced multi-organ dysfunction syndrome (MODS). The study, titled "Discovering Subphenotypes and Endotypes in Pediatric Sepsis-Induced MODS: The DISPENSE Study", will leverage data from two...
- This Project Grant award of $455,000 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to decrease sepsis mortality in the pediatric population. The key products and services to be delivered include: Developing an AI-guided early sepsis identification tool to enable timely diagnosis and treatment. Performing sepsis phenotyping and creating digital twin patient models to predict personalized treatment responses....
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $607,274 to study the long-term neuroimaging and neuropsychological outcomes in individuals born very preterm. The awardee, Children's Hospital of Orange County (CHOC), will conduct a longitudinal study spanning 27 years to examine brain development trajectories and cognitive...
- The Children's Hospital of Philadelphia (CHOP) received a $147,037 Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports a study to identify optimal electrophysiological markers for predicting developmental outcomes in infants. The research will examine the similarity between resting-state and auditory electroencephalography...
- This Project Grant award of $186,221 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), aims to develop personalized therapies for pediatric sepsis. The primary objectives are to augment sepsis phenotypes through the integration of high-frequency physiologic data with electronic health record data, and to retrospectively identify sepsis subtypes that may respond differently to various...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $588,566 to the University of Maryland, Baltimore to conduct a cross-disciplinary study on the long-term neurodevelopmental and school readiness impacts of in-utero HIV exposure on children in Sub-Saharan Africa. The research aims to establish a core team of investigators who can...
- This federal Project Grant award of $2,375,939.00 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) is funding a research study on "Neural Markers of Late Language Emergence in Preschool Children Born Very and Extremely Preterm" at The Children's Hospital of Philadelphia (CHOP). The research aims to investigate the neural mechanisms underlying delayed language development in children born prematurely. The award was made on September 10,...
- This $160,056 Project Grant awarded by the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to optimize antibiotic use and improve understanding of developmental pharmacokinetics in newborn infants. The key objectives are to: (1) quantify maternal antibiotic concentrations (ampicillin, gentamicin, vancomycin, clindamycin) in maternal and umbilical cord blood; and (2) perform...
This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $181,438 to The Children's Hospital of Philadelphia (CHOP) to conduct a prospective longitudinal study on neurocognitive outcomes and recovery trajectory for 180 school-aged pediatric sepsis survivors over 12 months. The key objectives are to evaluate the prevalence of new neurocognitive morbidities at 3 months after hospital discharge, the trajectory of neurocognitive recovery through 12 months for children with and without acute brain dysfunction during sepsis, and the association between high anticholinergic exposures during sepsis and acute brain dysfunction. The study leverages CHOP's robust research infrastructure and resources to address critical knowledge gaps on the lasting neurocognitive impacts of pediatric sepsis, which affects 100,000 children annually in the U.S. and 25 million worldwide.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $181.4k | 8/11/25 |