Project Grant K23GM163229
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $462,981 under the Biomedical Research and Research Training program (CFDA 93.859) to conduct a five-year research initiative addressing sepsis biology and clinical outcomes. The research program, which commenced August 15, 2025 and concludes July 31, 2030, leverages modern biobanks and electronic health record-linked databases to...
- Federal Project Grant Award Summary The University of Florida's Division of Sponsored Research received a $422,125 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859) effective September 1, 2025, through August 31, 2030. This five-year research initiative investigates myeloid-derived suppressor cells (MDSCs) in the immunological endotyping and intervention of chronic critical illness (CCI) following...
- Federal Grant Award Summary Loyola University of Chicago's Health Sciences Campus received a $423,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 5, 2025, with a completion date of June 30, 2030. The award supports a prospective research initiative focused on developing novel prognostic strategies for burn sepsis, a leading cause of mortality in severe burn injury...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Feinstein Institutes for Medical Research a $162,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 5, 2025, with completion targeted for July 31, 2030. The award supports comparative biomedical research investigating the mechanistic differences between regulated host immune responses to uncomplicated infection and dysregulated...
- Federal Project Grant Award Summary Vanderbilt University Medical Center received a $454,336 Project Grant award effective September 1, 2025, through June 30, 2029, under the National Institute of General Medical Sciences' Biomedical Research and Research Training program (CFDA 93.859). The grant supports fundamental biomedical research investigating the fibrinolytic-inflammatory axis and its role in severe trauma adverse outcomes. The research will employ a clinically relevant murine trauma...
- Federal Grant Award Summary Bloodworks, doing business as Puget Sound Blood Center and Program, received a $504,644 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) awarded on August 15, 2025, with completion anticipated by July 31, 2030. The grant supports a five-year research initiative investigating platelet-mediated CD8+ T cell interactions in sepsis-associated chronic critical illness...
- Federal Grant Award Summary Rutgers The State University of New Jersey, School of Nursing, received a $425,302 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 1, 2025, with a completion date of August 31, 2030. This five-year research initiative, led by the Poole Lab, focuses on elucidating the novel regulation of fibrinogen expression and function as a pro-inflammatory...
- Federal Project Grant Award Summary Baylor College of Medicine received a $400,000 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), awarded August 1, 2025, with completion targeted for July 31, 2030. The award funds research to create a comprehensive atlas of the cereblon (CRBN) interactome and accelerate molecular glue degrader (MGD) discovery. Researchers will identify and characterize potential...
- Federal Grant Award Summary Baylor College of Medicine received a $752,618 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 2, 2025, through May 31, 2030. The award funds research investigating the role of inflammation in postoperative atrial fibrillation (POAF), a common complication of cardiothoracic surgery occurring in 10-50% of cases. The research will deliver comprehensive...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Massachusetts General Hospital a Project Grant of $197,640 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 16, 2025, with a completion date of June 30, 2030. This award supports an investigator-initiated research project led by an Instructor in Medicine at Harvard Medical School and Assistant in the Division of Infectious Diseases at MGH. The project...
Baylor College of Medicine received a $181,440 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective February 1, 2026, through January 31, 2031. The award supports investigator-initiated research examining the role of interleukin-1 beta (IL-1B) and fibrin(ogen) interaction in sepsis-induced coagulopathy (SIC), a condition affecting approximately 60% of severe sepsis patients. The research will deliver scientific knowledge addressing how IL-1B bound to fibrin(ogen) alters clot characteristics and neutrophil activation in sepsis. The funded research encompasses two primary investigative aims designed to advance understanding of SIC pathogenesis. Aim 1 will use biochemical and cellular biology techniques to characterize how IL-1B bound to fibrin(ogen) affects clot formation, lysis, density, and stability in both human and swine septic plasma samples. Aim 2 will isolate and study neutrophils from sepsis patients to determine how IL-1B bound to fibrin(ogen) potentiates neutrophil activation and the release of neutrophil extracellular traps (NETs), with systematic pathway blocking to identify critical receptor mechanisms. These research activities will generate fundamental biological insights applicable to understanding and potentially improving treatment outcomes for sepsis-induced coagulopathy in pediatric and adult patient populations.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $181.4k | 1/30/26 |