Project Grant K23EY038872
- The National Eye Institute awarded Oregon Health & Science University $498,180 on September 1, 2026, under the Vision Research program (CFDA 93.867) to develop and apply novel optical coherence tomography (OCT) methods for detecting and monitoring photoreceptor changes associated with age-related macular degeneration. The project runs through August 31, 2030, with performance based in Portland, Oregon. Aim 1 investigates cone photoreceptor function impairments in AMD through advancement of...
- The National Eye Institute awarded Oregon Health & Science University $264,435 on May 1, 2026, under the Vision Research program (CFDA 93.867) to define the pathophysiology of microcephaly and chorioretinopathy (MCCRP) associated with defects in the gamma-tubulin ring complex. The project will use conditional knockout mouse models and tamoxifen-inducible endothelial cell-specific Cre recombinase to test the hypothesis that tubgcp4 and tubgcp6 serve critical roles in retinal and brain...
- The National Eye Institute awarded The Schepens Eye Research Institute Inc. $506,030 on September 1, 2026, under the Vision Research program (CFDA 93.867) to develop an open-source solution for exporting and integrating optical coherence tomography data across institutions. The project addresses a critical barrier in ophthalmic research: OCT imaging data from multiple manufacturers is stored in over ten proprietary, undocumented formats with export tools that are prohibitively slow—exporting a...
- The National Eye Institute awarded $753,787 to The General Hospital Corporation (doing business as Massachusetts General Hospital) on August 1, 2026, under the Vision Research program (CFDA 93.867) to develop low-cost ultra-widefield retinal optical coherence tomography (OCT) technology based on photonic-electronic integration. The project addresses cost barriers that limit clinical availability of OCT instrumentation used to detect and monitor diabetic retinopathy, age-related macular...
- The National Eye Institute awarded The Ohio State University $747,274 for Project Grant R01EY036506 on July 1, 2026, under the Vision Research program (CFDA 93.867). The award funds development of a pan-retinal optical coherence tomography (OCT) system capable of imaging the entire ocular globe extending to the ora serrata in living human eyes without image stitching. This technological innovation will enable the first opportunity to study ocular shape changes in response to refractive error...
- The National Eye Institute awarded the University of Oregon $670,232 on August 1, 2026, under the Vision Research program (CFDA 93.867) to support research on the molecular mechanisms of Fuchs' endothelial corneal dystrophy (FECD) associated with CUG-trinucleotide repeats in the TCF4 gene. The project develops and employs novel in vivo and in vitro models to determine whether the (CTG)N repeat expansion in intron 2 of the TCF4 gene causes FECD by altering TCF4 expression or through toxic effects...
- The National Institutes of Health Office of the Director awarded Oregon Health & Science University $455,322 on September 15, 2025, under the Trans-NIH Research Support program (CFDA 93.310) to develop software tools for creating standardized multimodal electronic health record datasets in ophthalmology research using artificial intelligence. The project will develop AI-driven tools, including natural language processing and large language models, to integrate and standardize multimodal...
- The National Eye Institute awarded The Schepens Eye Research Institute $858,394 on August 1, 2026, under the Vision Research program (CFDA 93.867) to develop multimodal foundation models for eye disease screening and prognosis. The research develops a vision-language foundation model trained on pairs of retinal images and clinical notes to enable downstream supervised models for detection and progression prediction of age-related macular degeneration, diabetic retinopathy, and glaucoma. The...
- The National Eye Institute awarded The New England College of Optometry $371,997 on June 1, 2026, under the Vision Research program (CFDA 93.867) to test a novel emmetropization mechanism model based on spectral and spatial opponent information in young children with myopia. The project will investigate how the retina controls eye growth and refraction through a blue-versus-yellow spectral-opponent mechanism. The research tests whether imbalances in retinal spectral and spatial...
- The National Eye Institute awarded the University of Washington $622,804 under the Vision Research program (CFDA 93.867) on August 1, 2026, to establish the cellular and molecular basis of the cone optoretinogram and standardize methods for clinical application. The cone optoretinogram measures length changes of individual human cone outer segments at nanometer-millisecond scale in response to light, using adaptive optics and optical coherence tomography. The research aims to develop...
The National Eye Institute awarded Oregon Health & Science University $237,341 on August 1, 2026, to develop curvature and color correction techniques for ultrawidefield optical coherence tomography imaging of the retina under the Vision Research program (CFDA 93.867). The project addresses fundamental limitations in current OCT technology by applying GPU-accelerated ray tracing for geometric reconstruction of the retina to eliminate distortion and curvature artifacts in widefield imaging, and by developing a novel Color-OCT algorithm that uses multiple-wavelength light simulation on structural OCT data to generate synthetic color fundus images. The work aims to enable high-resolution complete reproduction of the retina within a single imaging modality, reducing reliance on pupillary dilation and clinical examination. The recipient will also apply curvature-corrected techniques to two-dimensional fundus photography and scanning laser ophthalmoscopy to improve geometric measurement accuracy for clinical trial endpoints and quantitative biomarkers. Performance occurs in Portland, Oregon over the five-year period from August 1, 2026, through July 31, 2031. The assistance type is a Project Grant, an investigator-initiated research award supporting the work of a principal investigator at an academic medical center.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $237.3k | 8/4/26 |