This Project Grant award of $583,732 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research on molecular prediction, disease progression, and type 2 diabetes (T2D) phenotypes in South Asians. The key objectives are to: Investigate genetic associations with T2D and prediabetes phenotypes, develop polygenic risk scores, and explore associations between genetic...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,439,769 project grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Southern California. This 5-year study, titled "PFAS Exposure and Diabetic Kidney Disease in Youth with Type 2 Diabetes: A Multi-Omic Approach for Prevention and Treatment," aims to investigate the link between exposure to per- and polyfluoroalkyl substances...
This Project Grant award, funded by the Department of Health and Human Services' National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310), provides $324,883 to support a pilot trial of an intervention to improve initial type 2 diabetes self-management among younger adults with children. The project aims to develop an effective behavior change intervention that can influence long-term diabetes-related health outcomes during the critical first year following...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $711,791 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Kaiser Foundation Hospitals, doing business as Kaiser Permanente. The grant will fund a longitudinal cohort study to investigate the incidence, time trends, and risk factors for type 2 diabetes among Asian American, Native Hawaiian, and Pacific Islander adolescents and young adults in...
This $698,646 federal Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to study the functional and disease relevance of distinct pancreatic beta-cell subtypes, with a focus on understanding their epigenetic regulation and relationship to type 2 diabetes (T2D). The research will use novel single-cell epigenomic tools, conditional...
The federal Project Grant award R01DK142026, in the amount of $1,089,491, was granted by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award aims to deliver novel statistical methods, computational algorithms, and user-friendly software to study individual health trajectories relevant to disease onset and progression for biobank-scale real-world data. The research will...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $695,295.00 to study the developmental trajectories of reinforcer pathology and childhood obesity. The project will assess how the reinforcing value of food and physical activity, as well as delay discounting, change throughout childhood and adolescence, and how these...
This federal Project Grant award of $248,915.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research aimed at "Unravelling the Role of Epigenetics and Cytokines in Type 2 Diabetes among African-Ancestry Populations." The key objectives are to infer causal relationships between lifestyle factors, genetic regulatory...
This federal Project Grant award of $706,199 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to uncover the mechanisms of NAD depletion in obesity-induced pancreatic beta cell dysfunction and test strategies to restore beta cell mass and function in type 2 diabetes models. The award aims to define changes in NAD biosynthesis and degradation pathways...
This Project Grant award of $400,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to explore the role of insulin resistance in the development of renal disease during prepubertal childhood obesity. The research aims to investigate how insulin resistance alters glucose transport and energy metabolism in renal proximal tubules, potentially leading to...