This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $333,000 to the University of Connecticut Health Center to conduct a randomized, double-blind, controlled pilot study on the effectiveness and safety of a once-daily versus twice-daily administration of levothyroxine (LT4) and liothyronine (LT3) combination therapy for the...
This $241,130 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research by the Regents of the University of Michigan to study adaptive responses to complete thyroglobulin gene knockout. The award period runs from August 16, 2024 to March 31, 2027. The Diabetes, Digestive, and Kidney Diseases Extramural Research program funds a wide...
This Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund a training program to nurture the next generation of leaders in diabetes, metabolism, and endocrinology research. The $298,427 award, effective July 1, 2024 through May 31, 2029, will support post-doctoral trainees at the Vagelos College of Physicians & Surgeons of Columbia...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), aims to determine the role of thyroid hormones and the enzyme type 3 deiodinase (DIO3) in driving sex-specific cardiovascular health outcomes. The $163,344 grant, awarded on September 1, 2024, will support the University of Colorado-Denver in investigating whether cardiac DIO3 expression differs between sexes following myocardial...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $143,968 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System Incorporated. The grant, effective from December 19, 2024 to November 30, 2026, will fund research to examine early markers of hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA) and...
This Project Grant award of $1,089,491, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop novel statistical methods, computational algorithms, and user-friendly software to study individual health trajectories relevant to disease onset and progression for biobank-scale real-world data. The award will fund research at the University of California,...
This Project Grant award, valued at $240,725.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The purpose of the research is to investigate how proinflammatory cytokines disrupt pancreatic beta-cell Golgi structure and function, which may explain early defects in beta-cell secretory function observed in type 1 diabetes. Specifically, the project aims to...
This federal Project Grant award of $999,615.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports the development of a long-acting parathyroid hormone (PTH) derivative, EXT608, for the treatment of hypoparathyroidism. The award will fund a second clinical study in healthy volunteers to evaluate the safety and tolerability of multiple doses of EXT608, as well as...
This federal Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the cardiometabolic benefits of reducing iatrogenic hyperinsulinemia in individuals with type 1 diabetes (T1DM) through the use of insulin adjunctive therapy. The $340,747 award, with a start date of September 1, 2024 and an ultimate completion date of July 31,...
This $553,545 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program supports research aimed at understanding the mechanisms that regulate allelic expression of the Gsα subunit of the stimulatory G protein, and how this impacts hormone signaling and the development of diseases like pseudohypoparathyroidism. The principal investigator and awardee, The...