Project Grant K23AR085189
- This Project Grant award of $139,895.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research into the link between inflammatory arthritis and the development of cardiovascular disease. The key objectives are to investigate whether "trained immunity" - the phenomenon where innate immune cells become reprogrammed to respond more efficiently to a...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will provide $147,917 to Brigham & Women's Hospital Inc. over a 5-year period from January 1, 2025 to December 31, 2029. The key objectives of this award are to: 1) Recruit rheumatoid arthritis (RA) patients and assess their cardiovascular disease risk using high-sensitivity cardiac troponin...
- This $527,760 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will fund research on the role of endogenous retroviruses in autoimmune diseases like rheumatoid arthritis (RA). The award to the University of California, San Francisco will support a study to identify the specific antigens and mechanisms by which self-reactive T cells evade tolerance and...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) will support a five-year research plan to determine the pathogenic roles of granzyme K-expressing CD8 T cells in rheumatoid arthritis synovial tissue. The $382,537 award to the University of Colorado-Denver will investigate the effector mechanisms of these T cells using in vivo, in vitro, and in situ approaches. The research...
- The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $529,616 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to Brigham & Women's Hospital Inc. to conduct research on the role of Notch signaling and fibrosis in treatment-resistant rheumatoid arthritis. The project aims to define the molecular mechanisms by which Notch signaling regulates transforming growth factor beta (TGF-β) signaling in...
- This $358,000 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research at Brigham & Women's Hospital to elucidate social determinants of health and mental health needs in order to achieve equity in rheumatic disease care. The award will fund a 2-year study that leverages data from the All of Us research program to: Assess the effects of...
- This federal Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), supports research under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The $1,528,344 award to The Trustees of Columbia University in the City of New York aims to identify oxidized cysteine residues within ryanodine receptor type 1 (RyR1) channels that contribute to abnormal calcium handling in skeletal muscle weakness associated with...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $170,101 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to Brigham & Women's Hospital, a subsidiary of Partners Healthcare System, for a project titled "Dissecting the Spatial Heterogeneity of Synovial Inflammation in Rheumatoid Arthritis". The project aims to systematically characterize the spatial heterogeneity of synovial inflammation in rheumatoid...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research to investigate the molecular mechanisms of TAK1 regulation in rheumatoid arthritis (RA). The $1,407,925 award to Washington State University, effective August 12, 2025 through July 31, 2028, will focus on understanding how TAK1, a key signaling mediator, regulates the...
- This $548,828 Project Grant was awarded on September 21, 2023 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant was awarded to Knoubis Bio Inc., a for-profit organization based in California, to support research on a non-immunosuppressive disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis. The project aims to develop a new therapeutic approach...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846), provides $172,034 to the University of Nebraska Medical Center (UNMC) to support research into the mechanisms driving heightened risk of heart failure in individuals with rheumatoid arthritis (RA). The research aims to identify molecular factors and epidemiological determinants of early myocardial dysfunction and clinical heart failure development in the RA patient population. Key activities involve initiating a new prospective RA cohort with comprehensive cardiac risk assessment, biospecimen collection, and advanced cardiac imaging to characterize the interplay between inflammatory responses, fibrotic mediators, and comorbidity burden as drivers of cardiovascular disease in RA. This work will inform the development of strategies to improve heart failure prevention and management for this high-risk patient group. The award commenced on Aug 15, 2025 and is scheduled for completion on Jun 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $172.0k | 8/12/25 |