The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $715,957 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to Northwestern University to conduct research on the mechanisms underlying interferon-induced T peripheral helper (Tph) cell differentiation in systemic lupus erythematosus (SLE). The project, which runs from March 2025 to February 2030, will apply cutting-edge biochemical, epigenetic, and genetic approaches to...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The Medical University of South Carolina (MUSC) a $365,420 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to study the role of the SLE causal variant NCF1.PR90H in promoting kidney damage. The 2-year project aims to investigate how this genetic variant impacts the function of the NADPH oxidase complex and contributes to systemic lupus erythematosus...
This $194,700 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to characterize the biobehavioral basis of cognitive dysfunction in childhood-onset systemic lupus erythematosus (cSLE). The grant, awarded to The Children's Hospital Corporation (doing business as Boston Children's Hospital), will investigate functional central...
This $216,113 federal Project Grant award, issued by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to investigate the mechanism of hematological abnormalities in systemic autoimmunity. The research aims to characterize impairment in hematopoietic stem cells (HSCs) in a mouse model of systemic lupus erythematosus (SLE)-like disease, including the...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $297,940 to Case Western Reserve University from August 15, 2024 to July 31, 2026. The purpose is to develop patient- and parent-driven outcome measures for evaluating glandular inflammation and its flares, and their impact on quality of life and mental health for clinical trials related to...
This $206,016 Project Grant was awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant funds a 4-year study to define the clinical characteristics and progression of chronic lung disease in children with systemic juvenile idiopathic arthritis (SJIA-LD), validate biomarkers of disease activity, and develop patient-reported outcome measures for this condition....
This $375,100 federal Project Grant award was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant funds a study to investigate the interplay between nucleic-acid-dependent phase separation and immune responses against cyclic GMP-AMP synthase (cGAS) in systemic lupus erythematosus (SLE). The research aims to determine how changes in the biophysical...
The University of Colorado-Denver received a $367,900 Project Grant (R21AR082655) from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant will fund research to develop novel formulations of the drug imatinib that can enhance its delivery and accumulation in the kidney to improve treatment of glomerular kidney diseases, including lupus nephritis. The research team will...
This Project Grant award of $405,350.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research aims to characterize lipid droplets in macrophage subsets and determine if manipulating lipid droplet content can shift macrophage function, with the goal of uncovering new therapeutic targets for systemic lupus erythematosus (SLE). The award recipient is The...
This $358,000 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research at Brigham & Women's Hospital to elucidate social determinants of health and mental health needs in order to achieve equity in rheumatic disease care. The award will fund a 2-year study that leverages data from the All of Us research program to: Assess the effects of...