Project Grant K23AI189361
- The National Institute of Allergy and Infectious Diseases (NIAID) has awarded a $781,367 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Weill Medical College of Cornell University. The grant, awarded on January 25, 2024, will support research to define and maximize the impact of CD8+ T-cell selection on the landscape of HIV integration sites. The goal is to optimize strategies for eradicating the persistent reservoir of HIV-infected cells and achieve...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $240,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Northwestern University to conduct research on characterizing the HIV-1 viral reservoirs that persist even under antiretroviral therapy (ART). The 2-year project aims to identify the cellular sources and genetic diversity of the HIV-1 reservoirs, as well as study the sources and characteristics of the residual viremia...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3,568,644 Cooperative Agreement under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Wistar Institute of Anatomy and Biology, a non-profit biomedical research institute. The award aims to develop an individualized HIV cure strategy that combines enhanced neutralizing antibody responses, antiviral adaptive NK cells, and engineered cell-mediated effector strategies. The goal is to characterize...
- This $197,366 Project Grant was awarded on March 1, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The project aims to identify the molecular mechanisms that control the natural, immune-mediated restriction of X4-tropic HIV virus, which typically emerges only in late-stage HIV disease when the immune system is impaired. The research will utilize primary CD4 T cells, in vivo analyses in...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a Project Grant of $147,486.00 to the Icahn School of Medicine at Mount Sinai (ISMMS) in New York, NY. The grant, awarded on January 26, 2025, will support research to characterize the immune landscape and define the mechanisms of immune dysfunction in chronic hepacivirus infection, using the Norway rat hepacivirus (NRHV) as a model....
- This Project Grant award of $856,202 was provided by the National Institute of Allergy and Infectious Diseases (NIAID), which oversees the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program. The award will fund a 5-year study led by researchers at the University of California, San Francisco (UCSF) to investigate the role of IL-10 and IFN signaling in controlling the HIV reservoir and achieving functional HIV cure. The project aims to determine if enhancing IL-10 and...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $859,992 Project Grant to Yale University for the "Molecular Investigations of HIV-1 Maturation Pathways and Inhibitor Actions in situ" research project. The grant, funded under NIAID's Allergy and Infectious Diseases Research Program (CFDA 93.855), aims to use advanced in-situ cryo-electron microscopy and tomography techniques to visualize the structural transitions of the HIV-1 virus during the maturation...
- This Project Grant award of $149,389, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), supports research to characterize the clonal landscape of the HIV reservoir in CD4 cells. The awardee, Weill Medical College of Cornell University, will isolate and culture pure CD4 HIV reservoir clonal populations to phenotypically, genotypically, and functionally analyze them. This includes...
- This $243,713 Project Grant awarded on January 27, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program supports research to characterize mechanisms by which HIV-infected macrophages evade antibody-dependent cell-mediated cytotoxicity (ADCC) by natural killer (NK) cells. The objective is to determine how infected macrophages, which serve as a physiologically relevant viral reservoir, resist NK cell...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $806,208 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to Weill Medical College of Cornell University. The project, titled "Spatial Omics to Understanding HBV Control in People with HIV Coinfection," will leverage cutting-edge spatial proteomic and transcriptomic technologies to analyze the impact of HIV-related immune suppression and restoration on the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $192,268 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Icahn School of Medicine at Mount Sinai (ISMMS) to assess the effects of proposed HIV cure strategies in the gut-associated lymphoid tissue. This 5-year award, starting on August 26, 2025, aims to investigate the impact of HIV cure approaches on the viral reservoir located in the gut, as a large proportion of the reservoir resides in this tissue and can influence the peripheral circulation. The project, led by Dr. Francesca Cossarini, an infectious diseases assistant professor and current KL2 scholar at ISMMS, will evaluate cellular responses to cure strategies in the gut beyond just the peripheral blood, which has been the primary focus of prior studies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $192.3k | 8/26/25 |