This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund research to develop a new approach for analyzing the transcriptional control of virulence in the human fungal pathogen Aspergillus fumigatus. The $249,749 award will support the expression of an anti-GFP nanobody fused to a mammalian E3 ligase enzyme, which can trigger the proteolysis of GFP fusion proteins in A....
This $838,320 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) funds research to define the genetic determinants of Aspergillus fumigatus pathogenicity in the context of Bruton's tyrosine kinase (BTK) inhibitor cancer therapies. The research aims to uncover novel fungal factors that enable invasive aspergillosis in patients receiving BTK inhibitor treatments, which have been...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $642,775 to the University of California, Davis to accelerate the discovery of new antifungal peptides. The research will leverage the university's one-bead one-compound (OBOC) combinatorial technology and screening strategies to rapidly identify and optimize novel antifungal agents with desired physiochemical...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $871,154 to Virginia Polytechnic Institute & State University (Virginia Tech) to elucidate the molecular mechanisms by which the fungal pathogen Aspergillus fumigatus responds to the antifungal drug caspofungin. The research aims to determine the role of the septin cytoskeleton in mediating the fungistatic response...
This $262,098 federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to develop and characterize human induced pluripotent stem cell (iPSC)-derived neutrophil therapies against invasive pulmonary aspergillosis (IPA). The primary objectives are to: 1) assess the ability of iPSC-derived neutrophils to inhibit the growth of two common Aspergillus fungal...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund a $781,129 study to validate and extend an Integrated Host/Microbe (IHM) metagenomic diagnostic for lower respiratory tract infections (LRTIs) in critically ill children. The study aims to: 1) independently validate the performance of the existing IHM LRTI diagnostic classifier; 2) develop a host gene expression...
The National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. Department of Health and Human Services, has awarded a $300,156 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to Intact Genomics Inc., a minority-owned small business. The funding will support research to identify new antifungal compounds with novel mechanisms of action from filamentous fungi. The key objectives are to demonstrate the use of Aspergillus nidulans as a...
This $300,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to discover and develop new, more potent antifungal therapies for treating invasive fungal infections such as cryptococcosis, candidiasis, and aspergillosis. The funding will support the continued screening of chemical libraries to identify lead compounds that selectively inhibit the fungal ceramide synthase 1...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $207,370 to Duke University to investigate the role of the sigma factor SigE in modulating mycobacterial survival within granulomas, using a zebrafish-Mycobacterium marinum model. The research aims to uncover novel bacterial cell envelope components that impact both mycobacterial survival and the host immune...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $196,344 to Emory University to conduct research on identifying immune biomarkers that can predict outcomes in solid organ transplant patients with bloodstream infections. The key objectives are to: 1) identify cytokine, chemokine, and biomarkers associated with septic shock and 30-day mortality in these...