This $737,342 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports the development and validation of advanced imaging technologies to improve the detection and study of Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB). The key objectives are to: 1) Develop new imaging technologies capable of detecting single MTB bacteria in vitro and in vivo; 2) Use...
This $1,635,882 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to develop host-directed, pro-apoptotic drug therapies for the treatment of drug-susceptible and multi-drug resistant pulmonary tuberculosis (TB). The primary goals are to: 1) utilize novel pro-apoptotic host-directed therapies to shorten TB treatment regimens from the current 4-6 months...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $127,980.00 to The Johns Hopkins University for a five-year research project focused on integrating genomic and spatial data to develop more effective and efficient community-based tuberculosis (TB) screening and prevention interventions. The key objectives are to: 1) Refine estimates of subnational TB prevalence by...
This $209,750 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to leverage antibody-omics to prevent and detect tuberculosis (TB) in children affected by HIV. The key objectives are to: 1) Define antibody Fc features associated with protection from Mycobacterium tuberculosis (MTB) infection among infants with and without maternal HIV exposure, and 2) Identify biomarkers for...
This federal Project Grant award, valued at $1,350,312.00 and funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop a rapid phenotypic drug susceptibility testing system for tuberculosis (TB). The key products and services to be delivered under this grant include: Developing and optimizing a family of novel fluorescent trehalose probes (3HC-TRE and RMR-TRE) that can specifically detect...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is supporting the development and evaluation of a novel electrochemical lateral flow assay (ELFA) for the point-of-need detection of active tuberculosis (TB). The $238,500 award, provided from May 1, 2025 to April 30, 2027, aims to demonstrate the analytical and clinical performance of the ELFA, which combines the...
This $246,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports research to investigate the role of lung repair and regeneration pathways in tuberculosis (TB). The award aims to determine the functional role of the bone morphogenetic protein (BMP) signaling pathway in TB control and reactivation, as well as characterize the cellular mechanisms of BMP pathway activation during TB...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to identify and adapt an intervention to address common mental disorders (CMDs) among people being treated for tuberculosis (TB) in Uganda. The total award amount is $134,811 over a 5-year period from September 1, 2024 to August 31, 2029. The key objectives are to: 1) examine the relationship between CMDs and TB...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support the development of tools to facilitate preventive therapy for children and adolescents exposed to tuberculosis (TB) in their homes in Peru. The $212,636 award to Socios En Salud Sucursal Peru, a non-profit healthcare organization, aims to (1) derive a risk score to predict chest X-ray...
This $1,413,007 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support the development and evaluation of the CRISPR-TB diagnostic tool for detecting tuberculosis (TB) in children under 5 years old. The University of Washington is the primary grantee and will lead a large prospective study of 400 children with suspected TB. The project aims to expand upon prior successful...