This $400,000 Project Grant was awarded on August 15, 2024 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports pre-clinical studies to evaluate the prophylactic efficacy of a vaccine targeting two high-priority virulence factors of extraintestinal pathogenic E. coli (ExPEC), a leading cause of antibiotic-resistant infections and mortality worldwide. The studies aim to comprehensively...
This Project Grant award, valued at $828,820.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The project aims to investigate the molecular mechanisms by which the commensal bacterium Enterococcus faecalis can transition from a harmless gut resident to a pathogen that breaches the intestinal barrier and causes life-threatening systemic infections. Specifically, the research will...
The University of Washington received a $218,767 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award, with a performance period from February 2025 to January 2027, will fund a single-cell transcriptional atlas study of Giardia encystation, the process by which this parasitic eukaryote differentiates into dormant, encapsulated cyst forms. The project aims to use single-cell...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $304,280 to The Broad Institute, Inc. to conduct research focused on clarifying the risk factors for enterococcal infective endocarditis (IE). The key objectives are to: 1) analyze patient health and demographic data to identify characteristics associated with IE development, 2) perform a microbial genome-wide...
This $810,312.00 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund a comprehensive research project to investigate environmental reservoirs and transmission dynamics of multi-drug resistant Enterobacterales (MDR ENT) in the Chicago area. The project aims to: 1) profile MDR ENT and mobile antibiotic resistance genes in waterways to identify environmental reservoirs...
The federal Project Grant award R56AI168316 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $571,071 award, dated August 14, 2024, supports research at The Johns Hopkins University to investigate maternally acquired immunity and its role in protecting infants against enterotoxigenic E. coli (ETEC) infections. ETEC is a leading cause of diarrhea associated with significant morbidity,...
This $146,922 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to address critical knowledge gaps in chlamydia trachomatis (CT) prevention strategies. The key objectives are to: Characterize the frequency and factors associated with antibiotic use among men who have sex with men (MSM) in Seattle, WA, to inform the utility of doxycycline as a preventative...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $857,346 to the Fred Hutchinson Cancer Center in Seattle, Washington. The award supports research to investigate how activating and inhibitory signals, in the form of cytokines and metabolites, regulate the function of CD8 T cells in healthy and infected human tissues. The project aims to define the balance...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $477,226 to the University of Washington to conduct research aimed at understanding how microbial eukaryotes, such as amoebas, defend against giant viral infections, including those from the Megavirales family. The research will leverage advanced AI-driven protein structure prediction and environmental sampling...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $126,096 to the University of California, San Diego (UCSD) for research focused on understanding the mechanisms of microbial competition between Salmonella typhimurium and the gut microbiome. The research aims to elucidate the metabolic interactions and host responses that influence Salmonella colonization, with the...