This federal Project Grant award of $153,512 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to characterize the Circumsporozoite Protein (CSP)-specific memory B cell pool generated during Plasmodium infection or immunization in a murine model and relevant human clinical trial samples. The research objective is to understand how previous Plasmodium infection impacts the response to subsequent vaccination, and to...
The University of California, Davis received a $696,544 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to conduct research on the contractile attachment mechanisms of the Giardia parasite. The goal is to use biophysical and genetic approaches to study the ventral disc, a key virulence component of Giardia that allows it to attach to the intestinal epithelium and cause diarrheal disease. The five-year...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $557,745 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to Seattle Children's Hospital, doing business as Seattle Children's Research Institute, to develop a novel structure-based orthology approach to predict the function of uncharacterized proteins in eukaryotic parasite genomes. The project aims to 1) leverage AlphaFoldDB and FoldSeek to define domain-based structure orthology groups (DSOGs)...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $438,092 to the University of Georgia Research Foundation to conduct research on gene regulation in the Cryptosporidium parasite. The research aims to examine both transcriptional and translational aspects of gene regulation in Cryptosporidium, an important pathogen that causes significant diarrheal illness, especially in immunocompromised...
This federal Project Grant award, valued at $455,140.00 and funded by the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to investigate the thermosensory biology of soil-transmitted parasitic nematodes. The research, led by the University of Washington, focuses on understanding how temperature cues shape the specialized behavioral and physiological responses of these human parasites across their lifecycle....
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $202,500 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Regents of the University of Idaho. The grant, titled "Understanding the Chlamydial Developmental Cycle at the Single Cell Level," aims to develop a better understanding of the mechanisms regulating the developmental cycle of chlamydial bacteria, which cause significant human diseases such as pneumonia,...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,845,103 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Institute for Systems Biology. The grant aims to comprehensively characterize the protein expression of early mosquito-stage Plasmodium falciparum parasites to accelerate the discovery of transmission-blocking vaccine candidates.
The key products and services to be delivered under this grant include: 1) a...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $477,226 to the University of Washington to investigate antiviral systems in microbial eukaryotes, with a focus on how Acanthamoeba spp. defend against giant viruses in the Megavirales family. The project aims to uncover viral proteins that antagonize known viral restriction pathways in Acanthamoeba, as well as identify new antiviral systems...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of South Florida a Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the regulation of cell division in apicomplexan parasites. The $2,031,750 grant, awarded on April 12, 2024, supports a 5-year research project to study the unique cell cycle mechanisms of parasites like Plasmodium and Toxoplasma that cause significant human diseases. The project aims to...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $829,396 to the University of Washington to investigate the role of intestinal microfold (M) cells in creating an environment that fosters persistence and reactivation of the HIV reservoir. The project aims to:
Examine whether interaction with M cells increases immune activation of bystander CD4+ T cells and macrophages using...