This $2,307,536 federal Project Grant, awarded by the National Institute on Aging (CFDA 93.866 - Aging Research), will leverage a natural experiment to examine the effects of integrated palliative care on health service outcomes and disparities in Parkinson's disease and Lewy body dementia. The primary awardee, The Trustees of the University of Pennsylvania, will: Examine patterns of palliative domain care and disparities across U.S. Parkinson's specialty centers; and Test the effects of a...
The National Institute on Aging (NIA) awarded a Project Grant under the Aging Research Federal Grant Program (CFDA 93.866) to the University of Oklahoma Health Sciences Center to examine end-of-life care for persons living with dementia (PLWD). The $2,303,477 grant will leverage data from the Dementia Care Study (D-CARE), a 4-site randomized clinical trial, to compare documentation of PLWD advance care preferences, overall end-of-life care quality, and healthcare utilization in the last 6 months...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to study the impact of hospice care on the well-being of Alzheimer's disease (AD) patients and their family members. The $318,416 project will leverage natural experiments from the opening of new hospice facilities to estimate the effects of hospice utilization on patient outcomes such as pain management, depression, and activities of daily living. It will...
The National Institute on Aging (NIA), under the Aging Research (CFDA 93.866) Federal Grant Program, awarded a $199,375 project grant to Brown University. The project aims to examine whether hospices specializing in long-term care (LTC) settings provide better care to beneficiaries with Alzheimer's and related dementias (ADRD) compared to non-LTC hospices. Key objectives include: 1) describing individual, facility, and neighborhood-level characteristics associated with receiving care from LTC...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $791,086 to the Northern California Institute for Research and Education, Inc. (NCIRE) to develop computational models that can predict the presence of non-Alzheimer's disease neuropathological changes, such as Lewy body disease, TDP-43 proteinopathy, and cerebral amyloid angiopathy, in individuals with Alzheimer's disease neuropathological changes. The goal is to create clinically translatable...
This Project Grant award, identified as K01AG084878, was provided by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) federal grant program. The award supports the "COMPETENCE, AUTONOMY, RELATEDNESS, AND CONNECTIONS (CARE CONNECTIONS): A PEER-LED INTERVENTION DESIGNED WITH PARKINSONS DISEASE & RELATED DISORDERS CAREPARTNERS TO IMPROVE HOLISTIC SUPPORT" project. The $325,779 award will fund the development and pilot testing of a peer-led intervention to...
The National Institute on Aging (NIA) awarded a $596,258 Project Grant (CFDA 93.866 - Aging Research) to Weill Medical College of Cornell University to characterize and predict patient trajectories after live discharge from hospice among older adults with Alzheimer's disease and related dementias (ADRD). The project aims to apply longitudinal clustering methods to Medicare claims and encounter data to identify patient subgroups with heterogeneous trajectories after hospice live discharge,...
This Project Grant award of $2,278,636.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research to characterize and evaluate different nursing home clinician care models for residents with Alzheimer's disease and related dementias (ADRD). The project aims to understand the characteristics and outcomes of existing clinician care models, with a focus on the degree of co-management between nurse practitioners and physicians. The research will survey a nationally...
This Project Grant award of $7,704,350.00 from the National Institute on Aging (CFDA 93.866 Aging Research) supports a multi-year research initiative at the University of Pennsylvania to investigate the mechanisms underlying cognitive heterogeneity in synucleinopathies, a class of neurodegenerative disorders that includes Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease with Lewy bodies. The research program, conducted through four synergistic projects, aims to...
This $1,707,089 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research by Northwestern University to investigate synergistic approaches for enhancing endoplasmic reticulum (ER) proteostasis, protein trafficking, and lysosomal activity as potential treatments for dementia with Lewy bodies and Parkinson's disease-dementia. The research will use patient-derived induced pluripotent stem cell neuron models and mouse models to test the effects of...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research (CFDA 93.866) federal grant program, supports research to improve end-of-life care for hospitalized patients with Lewy body disorders. The $584,820 award, spanning Sep 2024 to Jun 2029, will enable Dr. Whitley Aamodt at the University of Pennsylvania to: 1) develop a risk-prediction model for 6-month mortality in hospitalized Lewy body disorder patients using Medicare data, and 2) create and validate a patient-centered instrument to measure end-of-life care quality in this population. This work aims to address critical knowledge gaps and guide future interventions to enhance end-of-life care for this vulnerable patient group.