Project Grant K22CA296473
- Federal Project Grant Award Summary Award Details: Baylor College of Medicine received a $197,600 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), awarded December 1, 2025, with completion targeted for April 20, 2027. The award supports biomedical research training and career development in cancer research aligned with the National Cancer Program's strategic objectives. Research Deliverables: The grant funds investigation into a...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Baylor College of Medicine a $882,470 Research Specialist (Clinician Scientist) Award under the Cancer Treatment Research program (CFDA 93.395) for the period September 1, 2025, through August 31, 2030. The award supports clinical leadership and trial development services focused on pediatric and adolescent cancer patients with hematologic malignancies. The primary deliverables include establishment and facilitation of a...
- Federal Grant Award Summary Dana-Farber Cancer Institute, Inc. received a $110,190 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) awarded on December 27, 2025, with a completion date of June 30, 2028. The award supports research training and career development in cancer immunotherapy, specifically focused on unraveling the mechanisms of neoantigen vaccine-induced epitope spreading (ES). The project will systematically investigate how...
- Federal Grant Award Summary Baylor College of Medicine received a $160,500 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), effective July 10, 2025, with completion targeted for June 30, 2027. The award funds the development and investigation of in vivo murine models to examine the role of caspase-2 in nucleophosmin-mutated acute myeloid leukemia (NPM1C+ AML). The research deliverables include the establishment of transgenic mouse...
- Federal Grant Award Summary Baylor University received a Project Grant award from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) to develop innovative artificial intelligence-driven methods for accelerating the discovery of dual-targeted cancer theranostic agents. The award, obligated on September 4, 2025, with a completion date of August 31, 2029, supports research focused on designing bispecific small molecule inhibitory conjugates...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant totaling $901,205 to Boston Children's Hospital under the Cancer Treatment Research program (CFDA 93.395) effective July 3, 2025, with a completion date of June 30, 2032. This research initiative focuses on identifying genome-wide changes in gene expression during early tumorigenesis and metastatic progression to improve immunotherapy efficacy. The project leverages genetically engineered mouse models...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $402,011 Project Grant to The University of Texas Southwestern Medical Center under the Cancer Biology Research program (CFDA 93.396) for the period May 1, 2026 through April 30, 2031. This five-year research project investigates the molecular mechanisms by which the KEAP1-NRF2 (Kelch-like ECH-associated protein 1–Nuclear factor erythroid 2-related factor 2) redox-sensing pathway regulates CD8 T cell adaptation to...
- Federal Grant Award Summary Baylor College of Medicine received a $681,330 Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) on May 13, 2026, with performance completion scheduled for April 30, 2031. The award supports research to dissect the mechanisms of epoxide hydrolase 2 (EPHX2)-deficient bladder cancer and identify metabolic and immunologic vulnerabilities that can guide precision medicine approaches. The research utilizes...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $663,340 Project Grant to the University of California, Berkeley under the Cancer Biology Research program (CFDA 93.396) to conduct fundamental research on regulatory T cell-mediated suppression of tumor elimination. The award, made on August 27, 2025 with completion targeted for July 31, 2030, will fund investigations into how the local ablation of intra-tumoral regulatory T cells (IT-Tregs) mobilizes natural killer...
- Federal Project Grant Award Summary Baylor College of Medicine received a $411,404 Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) awarded on August 20, 2025, with a completion date of July 31, 2027. This research initiative aims to identify genes with a significant deficit of loss-of-function (LOF) mutations in lung tumors, a novel approach to cancer-related gene identification. The project utilizes statistical regression modeling and...
The National Cancer Institute (NCI), under the Cancer Research Manpower program (CFDA 93.398), awarded Baylor College of Medicine a $191,681 project grant effective July 1, 2026, through June 30, 2029, to support research training and career development in cancer immunotherapy. The award funds investigative work focused on targeting the RNA helicase EIF4A to enhance anti-tumor immunity in triple-negative breast cancer (TNBC), a particularly aggressive breast cancer subtype with limited treatment options and poor patient prognosis. The research encompasses basic science investigations into Type I interferon (IFN) signaling mechanisms and the development of therapeutic strategies that improve tumor immune microenvironments and enhance sensitivity to immune checkpoint blockade and chemotherapy treatments. The project deliverables include mechanistic studies examining how EIF4A inhibition induces robust Type I IFN responses and cytosolic accumulation of double-stranded RNAs, as well as investigations into ADAR1 activation as an adaptive tolerance mechanism. Through preclinical models and translational research, the award supports the identification and validation of novel therapeutic vulnerabilities in TNBC that could improve treatment efficacy and patient outcomes. This training and research initiative aligns with the NCI's strategic priorities in cancer immunotherapy and workforce development for early-stage and established investigators pursuing independent research careers in oncology.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $191.7k | 6/9/26 |