This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $158,800.00 to The Curators of the University of Missouri, doing business as the University of Missouri at Kansas City (UMKC), for the period of September 1, 2024 to August 31, 2026. The funding will support research to investigate the structure, function, and therapeutic potential of cyclic beta-hairpin antimicrobial peptides as a strategy to combat antibiotic-resistant pathogens. Specifically, the research aims to: 1) biochemically analyze a dataset of synthetic beta-hairpin antimicrobial peptides to identify sequence features that promote antibacterial specificity, 2) examine how these peptides interact with and permeate different bacterial cell membranes, and 3) evaluate the accuracy of predictive data on how amino acid sequence variants impact the antimicrobial activity and toxicity of a promising natural beta-hairpin antimicrobial peptide. The findings from this research are expected to advance the understanding of this class of antimicrobial peptides and their potential as therapeutic agents against drug-resistant infections.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $158.8k | 8/30/24 |