Project Grant K22AI179795
- This $616,588 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to understand the molecular function of unstudied genes in the fungal pathogen Cryptococcus neoformans, a leading cause of fungal meningitis. The research team at the University of California, San Francisco constructed and phenotypically profiled a comprehensive gene deletion collection for C. neoformans to elucidate the...
- This Project Grant award of $802,499, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Program (CFDA 93.855), aims to characterize the genetic factors involved in tuberculosis (TB) susceptibility and their interaction with the immune system. The key objectives are to: 1) generate population-level genetic data on 5,000 case-control samples from diverse South African populations to identify genetic markers associated...
- This Project Grant award of $265,650 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to develop novel medicinal chemistry strategies to overcome multidrug-resistant tuberculosis (MDR-TB) and rifampicin-resistant TB (RR-TB). The research aims to establish the structure-activity relationship and mechanism of action of modified rifabutin analogs that demonstrate enhanced potency against...
- This Project Grant award of $749,594, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to study the role of the host sphingosine kinase 1 (SK1) pathway in controlling infection by the fungus Cryptococcus neoformans during immunodeficiency. The award recipient, The Research Foundation for the State University of New York (RFSUNY) doing business as Stony Brook University, will...
- This $811,396 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases under CFDA 93.855 Allergy and Infectious Diseases Research, is focused on understanding the mechanisms of lipid/metabolite and drug transport in Mycobacterium tuberculosis and related mycobacteria. The major objectives are to establish the molecular mechanisms and structures of three specific MMPL transporter proteins and their complexes with interacting partner proteins. Key activities include...
- This Project Grant award of $104,262, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to explore the relationship between genetic variants, transcriptional responses, and tuberculosis (TB) infection outcomes in macrophages derived from genetically diverse mice. The project aims to understand the basis for variability in TB infection outcomes, which may help identify ways to...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,041,944 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Rutgers, The State University of New Jersey. The grant will support research to understand the mechanisms underlying heterogeneous transmission of Mycobacterium tuberculosis (MTB) strains, as well as the immune responses of individuals who resist MTB infection despite exposure. The research aims to identify potential...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $186,451 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to the University of Maryland, College Park. The grant is for a project titled "A Murine Model for HIV/AIDS Associated Cryptococcal IRIS: Characterizing the Molecular Mechanism of CD4+ T Cell Migration to the Brain." The project aims to investigate the molecular mechanisms of CD4+ T cell migration to the brain during...
- This Project Grant award of $162,000.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Tulane University. The project aims to investigate the role of the LRRK2-G2019S genetic variant in promoting cell death pathways and susceptibility to chronic inflammatory diseases and infection, particularly with Mycobacterium tuberculosis. Key objectives include defining how the LRRK2-G2019S variant...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $813,373.00 to Rutgers, The State University of New Jersey to conduct research aimed at "Unraveling the Spectrum of Intrabacterial Amide Hydrolysis to Develop New Classes of Pyrazinoic Acid Prodrugs Against Pyrazinamide Resistant Mycobacterium tuberculosis". The 5-year project from Jun 2025 to May 2030...
This $160,640 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to Rutgers, The State University of New Jersey aims to determine whether genetic variants in the mechanistic target of rapamycin (mTOR) pathway are associated with increased susceptibility to cryptococcal disease. The key products and services to be delivered under this 2-year grant are: 1) Characterizing the immunologic consequences of mTOR deficiency and its impact on susceptibility to Cryptococcus using established murine models, and 2) Evaluating how patient-derived mTOR variants alter cell signaling and function in patient lymphocytes. The findings will elucidate the mechanistic link between human mTOR gene variants and specific susceptibility to cryptococcosis in previously healthy individuals, providing novel insights into this infectious disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $160.6k | 7/30/25 |