Project Grant K08NS140553
- This Project Grant award of $241,380 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) aims to advance the understanding of neurodevelopmental disorders (NDDs) and develop innovative therapies. The research program, led by researchers at Boston Children's Hospital, will use single-cell epigenomic technologies to link pathogenic variants in chromatin regulators, such as...
- This $539,999 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to investigate the role of the NKX2.1 homeobox transcription factor in nervous system development. The research, to be conducted by Kennesaw State University, will utilize the nematode Caenorhabditis elegans as a model organism to better understand how NKX2.1 and related...
- This federal Project Grant award from the Defense Health Agency, under the Military Medical Research and Development program (CFDA 12.420), provides $1,366,365.00 to The Children's Hospital of Philadelphia (CHOP) to conduct a research study titled "BRAIN CHARTS IN CHILDREN AND ADOLESCENTS WITH NEUROFIBROMATOSIS TYPE 1". The study aims to advance healthcare for children by improving the understanding of brain development in those with neurofibromatosis type 1, a genetic disorder that...
- The federal Project Grant award of $719,498 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) supports research at The Children's Hospital of Philadelphia Research Institute to elucidate the neurobiological functions of glycosylation and its role in congenital disorders of glycosylation (CDG). The research aims to identify the neurological impacts of disrupted...
- This $512,423 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at the University of Utah to investigate the role of the IGF2BP family of RNA binding proteins in brain development and their relationship to neurodevelopmental disorders. The research aims to elucidate how the fly orthologue IMP regulates the mRNA target...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Regents of the University of California, San Francisco (UCSF) on August 1, 2025 for $1,180,687. The purpose of this 8-year project is to investigate how neural stem cell niches transition from embryonic to postnatal stages in the human forebrain, with a focus on characterizing the different neural...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $897,250 project grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to St. Jude Children's Research Hospital Inc. The grant will fund an 8-year research program to investigate the physiological functions of biomolecular condensates, how they establish distinct identities, and the relationship between condensate dysfunction and the pathogenesis of neurological...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a 5-year, $220,050 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Children's Hospital of Philadelphia Research Institute. The grant aims to advance clinical trial readiness for SYNGAP1-related disorder (SYNGAP1-RD), a rare monogenic epilepsy associated with severe neurodevelopmental issues. The research project will prospectively follow a cohort...
- The National Institute of Child Health and Human Development (NICHD) awarded a $431,750 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Rutgers, The State University of New Jersey, to investigate how the cytokine interleukin-6 (IL-6) affects the proliferation, specification and gene expression of human and mouse secondary neural progenitor cells. The goal is to establish IL-6 as a key target for intervention to prevent neurodevelopmental disorders like...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $190,485 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Trustees of Indiana University (Indiana University Indianapolis) on February 4, 2025. The grant supports research to investigate the molecular mechanisms underlying differentiation failure in neuroepithelial stem cells with NF2 gene mutations, with the goal of identifying novel therapeutic...
The U.S. National Institute of Neurological Disorders and Stroke (NINDS) awarded a $221,400 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Children's Hospital of Philadelphia (CHOP). This 5-year grant, beginning on August 1, 2025, aims to investigate the role of the c-Jun N-terminal kinase (JNK) signaling pathway in neurodevelopmental disorders (NDDs) such as autism and intellectual disability. The project will utilize induced pluripotent stem cell (iPSC)-based disease models to examine the effects of genetic variants in the JNK pathway, including MAP4K4 and MAP2K4, on neuronal function. Additionally, the project will leverage biobank-scale data to identify novel gene-disease relationships associated with JNK-related genes and NDDs. The goal is to improve understanding of the molecular mechanisms underlying NDDs and inform the development of precision therapies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $221.4k | 7/29/25 |