Project Grant K08NS138686
- This Project Grant award of $438,625.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at the University of California, San Diego (UCSD) to characterize and augment a novel pro-survival mechanism in neurons during ischemic brain injury. The research aims to investigate the role of the protein INF2 in driving "actinification", a...
- The U.S. National Institute of Neurological Disorders and Stroke (NINDS) awarded a $125,685 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Leland Stanford Junior University (Stanford University). The funding will support the development of an injectable hydrogel with an integrated urokinase plasminogen activator (uPA) motif and plasmid DNA (pDNA) platelet-derived growth factor B (PDGFB)-lipoplexes to be loaded into the...
- This federal Project Grant award, valued at $492,749.00 and awarded by the National Institute of Neurological Disorders and Stroke (NINDS), supports the development of a novel non-invasive magnetic resonance imaging (MRI) technique called ratiometric dual contrast (RDUAL) pH-weighted MRI. The goal is to create an imaging tool that can accurately map the ischemic penumbra (tissue at risk of infarction) and evaluate the risk of reperfusion injury in acute ischemic stroke patients. This research,...
- This Project Grant award of $192,500 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to define the contribution of endothelial cell sphingolipid metabolism to outcomes of acute ischemic stroke in mice. The award, effective December 1, 2024, will enable the University of Utah to leverage innovative murine models and novel ceramide biosynthesis...
- This Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to investigate the role of complement-mediated inflammation in exacerbating stroke outcomes in mice with type 2 diabetes. The total award amount is $604,795.00 and the project period runs from December 1, 2024 to November 30, 2029. The awardee, Northern...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), provides $626,034 to The Regents of the University of California, San Francisco (UCSF) to conduct research on identifying cortical and brainstem regions contributing to partial hand function post-stroke. The research aims to investigate the neural mechanisms underlying the preserved ability...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support metabolomic research related to intracerebral hemorrhage (ICH) recovery. The $669,092 award, with a period of performance from May 2025 to April 2029, will leverage samples and data from two large genetic epidemiology studies of ICH to assess 5,400 metabolites and identify...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $541,109 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Washington. The 5-year grant, beginning January 1, 2025, will fund research to quantify myelin loss and recovery in ischemic stroke patients using a novel magnetic resonance imaging (MRI) technique called single-point macromolecular proton fraction (MPF) mapping. The...
- This federal Project Grant award of $770,502.00, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to understand the molecular mechanisms by which collagen IV regulates TGF-beta signaling and its role in cerebral small vessel disease (CSVD). The research will use mouse models to perform intravital imaging of the cerebral vasculature and...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $671,988 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Winifred Masterson Burke Medical Research Institute, Inc. The project focuses on understanding the cross-talk between two cell death pathways, sarmoptosis and ferroptosis, in the context of intracerebral hemorrhage (ICH), a type of stroke. The research aims to explore how the accumulation...
This $238,410 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS, CFDA 93.853) supports research at the University of California, San Francisco (UCSF) to identify protective and harmful mechanisms of acid-base physiology relevant to ischemic stroke. The project's objective is to determine how adjusting systemic and cerebral levels of carbon dioxide and hydrogen ions can improve metabolic supply, inhibit spreading depolarizations, and reduce stroke size in mouse models. The research will compare the effects of these physiological parameters on cerebral blood flow, cellular energy metabolism, and stroke outcomes. Additionally, the project will test whether elevated extracellular hydrogen ions can decrease the incidence of spreading depolarizations by inhibiting NMDA receptors. This grant award, effective from August 1, 2025 through May 31, 2030, supports the Principal Investigator's transition to becoming an independent investigator focused on improving clinical outcomes for severe ischemic stroke patients in the intensive care unit.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/16/25 | ||
| Not listed | $238.4k | 7/31/25 |