Project Grant K08NS136766

Award Date 1/15/25
Completion Date 12/31/29
Dollars Obligated $234K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
University City, MO 63130, USA
Similar Awards
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $431,750 R21 project grant (CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders) to Rutgers, The State University of New Jersey to study the role of the RIPK3 protein in protecting neurons from excitotoxicity during Zika virus infection. The two-year project will use a combination of pharmacogenetics, imaging, molecular biology, and electrophysiology to investigate how RIPK3...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund the validation of a novel treatment for glioblastoma (GBM) using oncolytic Zika virus. The awardee, Up Oncolytics, Inc., will conduct IND-enabling experiments to prepare this potential treatment for clinical trials. Key products or services to be delivered include demonstrating...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a 2-year, $544,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the Texas Biomedical Research Institute to characterize a novel mouse model for studying the neurological impacts of Chikungunya virus infection. The research aims to determine the mechanisms by which Chikungunya virus infects the brain and evaluate whether the mouse model develops the...
This $537,508 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to understand the role of endogenous zinc protoporphyrin (ZnPP) in intracerebral hemorrhage (ICH)-induced brain damage. The research aims to elucidate the mechanisms by which ICH triggers ZnPP formation and how ZnPP contributes to neurotoxicity, as well as evaluate...
This $769,115 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to advance the understanding of how neurotropic viruses, including flaviviruses and alphaviruses, can directly enter the central nervous system (CNS) through newly described meningeal structures called arachnoid cuff exit (ACE) points. The research team from The Washington University in St. Louis will...
This Project Grant award of $600,000 from the National Institutes of Health's Trans-NIH Research Support program (CFDA 93.310) supports research to elucidate the role of antibodies in the neurological effects of COVID-19, known as "NeuroCOVID-19". The overarching goal is to investigate how inflammatory immunoglobulin G (IgG) antibodies associated with SARS-CoV-2 infection may trigger activation and damage to brain cells and endothelial cells, leading to disruptions in brain...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is supporting research to investigate the role of T cells in promoting post-acute memory deficits after COVID-19 infection in mice. The $107,995 award to The Washington University, which runs from July 2025 to June 2027, will fund a study to determine how pathogenic CD4+ T cells are recruited to the central nervous...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is providing $635,386 to Duke University to conduct research on the pathogenic mechanisms of inflammatory subventricular zone injury in preterm infants. The research aims to define the immune signatures associated with the development of subventricular zone echogenicity, a predictor of...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Medical College of Wisconsin, Inc. (MCW) to study the impact of human cytomegalovirus (HCMV) infection on the development of human neural tissues. The $682,879 award, effective from January 24, 2025 to December 31, 2029, aims to: (1) define the transcriptional and cellular disruptions to developing human neural cells caused by...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,216,094 in funding to the University of California, San Diego to investigate a novel mechanism of dysfunctional mitophagy (selective autophagy of mitochondria) and its role in brain ischemia-reperfusion injury. The objective is to determine if inactivation of the...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, provides $234,359 to Washington University to conduct research on the role of the MERTK receptor in brain injury associated with congenital Zika virus infection. The research aims to investigate how increased MERTK signaling during prenatal and early postnatal Zika virus infection may mediate immune-driven neuronal injury, synaptic pruning, and functional connectivity abnormalities, leading to cognitive and behavioral deficits. This mentored career development award will provide the applicant, a pediatric neurologist, with formal training in animal models of early neurodevelopment, neuroimmunology, and developmental neuroscience research methods to support the proposed studies. The research is expected to advance the understanding of brain injury mechanisms in children with congenital Zika virus exposure and has broader implications for the effects of neuroinflammatory insults on the developing brain.

Generated 8/5/25, 2:55 AM