This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research into the complex neurological mechanisms underlying chronic pain. The $1,525,066 award, with a performance period from June 15, 2024 to May 31, 2029, will fund a multifaceted study conducted by the University of California, San Francisco (UCSF) to: 1)...
The federal Project Grant award R01NS136363, totaling $453,104.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant supports research to explore the role of two distinct subtypes of spinal projection neurons, TACR1- and GPR83-expressing, in conveying pain signals to the brain and their potential as therapeutic targets for chronic...
This federal Project Grant award, with ID R21NS137066, was issued by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award of $246,750 to The Trustees of Columbia University in the City of New York will fund research to investigate the role of the mesocortical glutamatergic pathway, which connects the ventral tegmental area to the prefrontal cortex, in the...
This Project Grant award from the National Institute of Neurological Disorders and Stroke, under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop a novel non-invasive high frequency trans-spinal magnetic stimulation (HF-TSMS) system for the treatment of neuropathic pain. The $3,565,780 grant supports experimental studies using rodent models at Massachusetts General Hospital (MGH) to assess pain responses via fMRI, as well as further efficacy and safety evaluations in...
This $351,097 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) establishes the Mass General Brigham Interdisciplinary Clinical Pain Research Training Program. The program will support 8-12 postdoctoral trainees over 5 years to expand the pool of early-career investigators in clinical pain research. Key focus areas include advancing health equity, understanding and treating chronic...
This National Institute of Neurological Disorders and Stroke (NINDS) Project Grant award of $242,061.00 under the Drug Use and Addiction Research Programs (CFDA 93.279) supports the establishment of the Mass General Brigham Interdisciplinary Clinical Pain Research Training Program. This program will provide a 2-3 year training and research experience for a diverse pool of postdoctoral fellows, with the goal of expanding the cadre of early-career clinical pain researchers capable of launching...
This federal Project Grant award of $405,000.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research at the University of Cincinnati to investigate the impacts of traumatic brain injury (TBI) on serotonin (5-HT) neuron function and its role in the development of neuropsychiatric disorders. The key objectives are to characterize TBI-induced alterations...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $643,262 to investigate the neural circuit basis for the relationship between chronic pain and depression. The research aims to systematically study the projections from the lateral habenula (LHB) brain region to the parabrachial nucleus and dorsal raphe nucleus,...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $560,934.00 in funding to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to conduct innovative research on neural coding and control of pain detection in the somatosensory cortex. The key research aims are to: 1) Define the temporal...
This Project Grant award of $628,133 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) grant program, supports research to understand the metabolic mechanisms underlying recovery from mild traumatic brain injury (TBI). The primary award to Rutgers, The State University, will investigate how the activation of the enzyme CYPIN can help regulate methionine levels and...
This $456,840 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program will fund research to investigate the role of pain-facilitating circuits in the brain in chronic pain development following mild traumatic brain injury (MTBI).
The research aims to characterize the functional and electrophysiological changes in descending "on-cells" within the rostral ventromedial medulla (RVM) brain region following MTBI, and determine their role in MTBI-induced hypersensitivity to postsurgical pain and headache. This will involve using chemogenetic techniques to manipulate on-cell activity, as well as in vivo calcium fiber photometry and ex vivo patch clamp recording to study longitudinal changes in on-cell function in a mouse model of MTBI. The findings are expected to establish the relationship between disruptions in brainstem pain modulation and the development of chronic pain after traumatic brain injury.