Project Grant K08HL186457
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant totaling $1,097,760 to The Regents of the University of California, San Francisco under the Cardiovascular Diseases Research program (CFDA 93.837) effective February 15, 2026, with completion scheduled for December 31, 2032. This research initiative aims to develop therapeutic interventions to block age-related pulmonary fibrosis and restore lung regeneration in idiopathic...
- Federal Project Grant Award Summary The University of California, San Francisco (UCSF) received a $1,376,933 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) effective August 1, 2025, with completion targeted for April 30, 2029. The award funds research into fibroblast-mediated resolution of basal metaplasia in lung fibrosis, specifically investigating how specialized alveolar fibroblasts expressing the...
- Federal Project Grant Award Summary The University of California, San Francisco received a $1,442,583 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct basic biomedical research on purinergic signaling mechanisms in idiopathic pulmonary fibrosis (IPF). The award, effective August 1, 2025 through May 31, 2029, funds investigative research aimed at identifying and characterizing the ATP receptor...
- Federal Project Grant Summary The University of California, San Francisco received a $182,060 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), with an award date of September 30, 2025 and completion date of November 29, 2026. This research award supports an investigation into the role of the senescence marker P16INK4A in alveolar epithelial stem cells during injury-triggered lung differentiation. The...
- Federal Project Grant Award Summary The University of California, San Francisco received a $190,998 Project Grant from the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), awarded August 1, 2025, with completion targeted for July 31, 2030. This research initiative, titled "Understanding Pulmonary Fibrosis Through the Integration of Complex Occupational and Environmental Exposure Assessments," delivers epidemiologic research...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant totaling $173,259 to the University of California, San Diego, with a performance period from September 1, 2025, through August 31, 2028, under the Cardiovascular Diseases Research program (CFDA 93.837). This grant supports fundamental research investigating the role of Kruppel-like factor-6 (KLF6) in lung development. The principal investigator will conduct research to delineate KLF6's...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1,113,961 Project Grant to The Regents of the University of California, San Francisco on August 10, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to support research investigating how centrioles direct mammalian development. The research focuses on understanding the molecular and cell biological mechanisms through which centriole defects contribute to congenital heart disease,...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $638,900 Project Grant to The Regents of the University of California, San Francisco on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837). This award funds research investigating the role of pathologic fibroblast subsets unique to silicosis, a chronic and potentially fatal fibrotic lung disease caused by inhalation of crystalline silica. The research will be...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $328,320 to The Regents of the University of California, San Francisco under the Cardiovascular Diseases Research program (CFDA 93.837) on August 1, 2025, with a completion date of May 31, 2030. This five-year mentored career development award supports Dr. Andrew Levine's transition to an independent academic physician-scientist position. The grant funds a structured research and training program...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a K08 Mentored Career Development Project Grant of $163,188 to The Regents of the University of California, San Francisco, with an award date of June 8, 2026, under CFDA 93.837 (Cardiovascular Diseases Research). This five-year grant, extending through May 31, 2031, funds research to characterize the role of CXCR6+ T-cells in immune checkpoint inhibitor (ICI)-induced myocarditis, a rare but life-threatening...
The National Heart, Lung, and Blood Institute (NHLBI) awarded $174,744 to The Regents of the University of California, San Francisco on June 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to support a K08 career development award for Dr. Anjali Jacob. This grant funds advanced training and mentored research in synthetic biology methods applied to pulmonary fibrosis research, with completion targeted for May 31, 2031. The award provides structured career development through three key components: (1) advanced training in synthetic biology techniques for modulating cell signaling pathways, (2) access to mouse models and patient tissue models for investigating transforming growth factor-beta (TGF-β) signaling mechanisms in idiopathic pulmonary fibrosis (IPF), and (3) comprehensive mentorship from a multidisciplinary team of scientists and physician-scientists to prepare the investigator for independent R01 grant applications. The research deliverables include development and characterization of novel cell-based delivery systems for targeting TGF-β inhibitors to specific lung cell populations in pulmonary fibrosis. Three specific research aims will evaluate synthetic notch receptor-based delivery targeting all lung cells (Aim 1), chimeric antigen receptor-based delivery targeting fibrotic regions (Aim 2), and related delivery approaches (Aim 3), using both preclinical mouse models and human IPF tissue samples. This work aims to generate new synthetic biology tools for researchers to modulate signaling pathways and study or treat IPF and other chronic lung diseases.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $174.7k | 6/15/26 |