Project Grant K08HL185930
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Regents of the University of California, San Francisco a $1.27M Project Grant (CFDA 93.837 – Cardiovascular Diseases Research) effective September 15, 2025, through June 30, 2030, to investigate the role of pathologic fibroblast subsets unique to silicosis. The research employs lineage tracing and single-cell RNA-sequencing (scRNA-seq) methodologies to elucidate how alveolar fibroblasts differentiate...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Regents of the University of California, San Francisco a Project Grant of $182,060 under the Cardiovascular Diseases Research program (CFDA 93.837) for research investigating the role of the senescence marker P16INK4A in alveolar epithelial stem cells during injury-triggered differentiation. The award, obligated on September 30, 2025, with a completion date of November 29, 2026, supports...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the Regents of the University of California, San Francisco a Project Grant of $1,097,760 (obligated February 15, 2026) under the Cardiovascular Diseases Research program (CFDA 93.837) to support a research initiative addressing age-related pulmonary fibrosis and lung regeneration through December 31, 2032. The research program will investigate the cellular and molecular mechanisms driving idiopathic...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Regents of the University of California, San Francisco a $778,504 Project Grant effective July 1, 2026, through February 28, 2030, under the Cardiovascular Diseases Research program (CFDA 93.837). This award supports mechanistic research investigating the molecular mechanisms controlling lung capillary specialization, plasticity, and function during early postnatal development. The research...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant totaling $173,259 to the University of California, San Diego, with a performance period from September 1, 2025, through August 31, 2028, under the Cardiovascular Diseases Research program (CFDA 93.837). This grant supports fundamental research investigating the role of Kruppel-like factor-6 (KLF6) in lung development. The principal investigator will conduct research to delineate KLF6's...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1,559,572 Project Grant to the Regents of the University of California, San Francisco on June 17, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The award supports fundamental research into the multiciliation cycle, a specialized cell cycle variant that coordinates the biogenesis of hundreds of centrioles and cilia in multiciliated cells. The project investigates how...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Stanford University $323,136 under the Cardiovascular Diseases Research program (CFDA 93.837) for the project "Dissecting Lung Spatial-Biological Niches in Early Fibrogenesis," effective September 1, 2025 through August 31, 2026. This Project Grant supports research aimed at elucidating the biological mechanisms driving early-stage lung fibrosis in interstitial lung diseases (ILDs), which affect...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Leland Stanford Junior University a Project Grant of $761,017.00 under the Cardiovascular Diseases Research program (CFDA 93.837) for the period of September 1, 2025, through June 30, 2029. This research initiative, titled "Human Pulmonary Neuroendocrine Progenitors in Lung Injury and Disease," focuses on advancing scientific understanding of pulmonary neuroendocrine cells (PNECs) and their...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant totaling $1,426,317 to the Regents of the University of California, San Francisco on August 20, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds research into pulmonary immune regulation and lung injury following pediatric hematopoietic cell transplantation (HCT), which affects up to 40% of pediatric HCT recipients and represents a major...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $107,752 Project Grant awarded September 12, 2025, by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award supports a research initiative titled "Epithelial Cell Mediated Fibroblast Activation Through CTHRC1-TGFB Signaling in Fibrotic Lung Diseases," with a completion date of August 31, 2027. The research...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $163,836 Project Grant to The Regents of the University of California, San Francisco on July 8, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). This K08 career development award funds a five-year research project (through June 30, 2031) investigating bidirectional signaling networks in pulmonary silicosis, a progressive fibrotic lung disease characterized by granuloma formation. The research addresses a re-emerging public health crisis, particularly among young countertop fabrication workers exposed to engineered stone dust, with over 70 documented cases in California since 2019 and at least 10 confirmed deaths. The project delivers fundamental research products aimed at dissecting the cellular and molecular pathways governing fibroblast and macrophage proliferation and fate determination in silica-induced lung injury. Building on single-cell RNA sequencing data identifying previously unrecognized fibroblast and macrophage populations within granulomas, the research will examine platelet-derived growth factor receptor (PDGFR) signaling in alveolar fibroblast expansion and macrophage colony-stimulating factor (CSF1) receptor signaling in macrophage survival and support. The outputs will advance mechanistic understanding of how fibroblasts provide trophic support for immune cell populations within granulomas, potentially informing future therapeutic interventions for silicosis and related fibrotic lung diseases.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $163.8k | 7/9/26 |