Project Grant K08HL183828
- The National Heart, Lung, and Blood Institute awarded the University of California, San Diego $1,601,981 on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate protein aggregation mechanisms in hematopoietic stem cells and their relationship to stem cell aging. The research examines how hematopoietic stem cells traffic misfolded proteins to aggresomes—cytosolic inclusion bodies that are substrates for selective autophagy—and tests the hypothesis...
- The National Institutes of Health National Heart Lung and Blood Institute awarded Trustees of Boston University $100,228 on December 12, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate enhancement of engraftment potential in human hematopoietic stem cells. The research addresses the challenge of preserving hematopoietic stem cell functionality during the ex vivo culture steps required for gene editing therapies. The project employs multi-modal profiling of...
- The National Heart, Lung, and Blood Institute awarded The Trustees of Columbia University in the City of New York $1.137883 million on April 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the dynamics and plasticity of the hematopoietic stem cell niche. The funded work defines niche dynamics and plasticity across development, regeneration, and hematological disease; uncovers the mechanisms regulating these processes; and develops approaches to enhance...
- The National Heart, Lung, and Blood Institute awarded $1.175 million to Icahn School of Medicine at Mount Sinai on April 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate hemogenic mesoderm heterogeneity, regulation, and function in the developing mammalian hematopoietic system. The research, led by Dr. Sturgeon, delineates the molecular and transcriptional mechanisms by which hemogenic mesoderm gives rise to embryonic hematopoietic programs. The work...
- The National Heart, Lung and Blood Institute awarded Cincinnati Children's Hospital Medical Center $182,551 on September 30, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to fund research on de novo lipid synthesis and hematopoietic stem cell (HSC) function. The research investigates how monounsaturated fatty acid (MUFA) synthesis, catalyzed by the enzyme stearoyl-CoA desaturase 1 (SCD1), maintains HSC regenerative capacity by supporting mitochondrial function. The...
- The National Heart, Lung, and Blood Institute awarded the Trustees of Boston University $150,342 on September 30, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to support research into the mechanisms of a conserved niche endothelial program directing hematopoietic stem cell migration. The research uses high-resolution in vivo imaging in zebrafish embryos paired with human cell culture systems to investigate how bone marrow endothelial cells facilitate the...
- The National Heart, Lung, and Blood Institute awarded the University of Florida $597,817 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop resources for enhancing hematopoietic stem cell transplantation outcomes. The research aims to humanize the bone marrow vascular niche to study hematopoietic stem cell and vascular interactions and function. The project will establish technologies to isolate and cultivate human primary endothelial cells from bone...
- The National Heart, Lung, and Blood Institute awarded the University of Massachusetts $425,971 under the Cardiovascular Diseases Research program (CFDA 93.837) on July 6, 2026, to develop a biomaterials-integrated microphysiological bone marrow chip model. The award funds development of a silicon-based perfusion chip platform that integrates demineralized bone paper and inverted colloidal crystal hydrogel scaffolds to recapitulate the structural and functional interdependence of bone and bone...
- The National Heart, Lung, and Blood Institute awarded The Trustees of The University of Pennsylvania $632,561 on August 20, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to identify and optimize signaling pathways that promote the maturation of pre-hematopoietic stem cells into long-term, multi-lineage adult-repopulating hematopoietic stem cells. The research focuses on transforming growth factor beta and bone morphogenetic protein signaling pathways, with emphasis on...
- The National Heart, Lung, and Blood Institute awarded Cincinnati Children's Hospital Medical Center $715,504 for Project Grant R01HL187582 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The recipient will investigate the regulation of long-lasting hematopoietic multipotent progenitors (MPPs) and the mechanisms by which immune signals shape their functional properties. The research addresses evolving understanding of hematopoietic cell production dynamics,...
The National Institutes of Health National Heart, Lung, and Blood Institute awarded the University of California, San Diego $168,795 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to support research on proteostasis in hematopoietic stem cell development. The project, titled "Proteostasis in Hematopoietic Stem Cell Development," addresses dysfunction in inherited bone marrow failure syndromes by investigating protein homeostasis disruption in developing hematopoietic stem cells (HSCs). The research tests the hypothesis that proteostasis impairment during HSC development drives bone marrow failure and examines whether proteostasis can serve as a biomarker of human HSC function. The recipient proposes that interventions buffering against proteostasis disruption could delay bone marrow failure in Diamond-Blackfan anemia syndrome, a disorder characterized by erythroid failure. The award funds protected time and laboratory research for a physician-investigator in training to develop expertise in developmental hematopoiesis and bone marrow failure, with the goal of developing targeted therapies to improve HSC function in pediatric bone marrow failure. The recipient will conduct work under the guidance of a primary mentor and advisory team at the University of California, San Diego in La Jolla, California. Period of performance runs from September 1, 2026, through June 30, 2031. This is a project grant, classified as assistance funding rather than a procurement contract.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $168.8k | 8/26/26 |