Project Grant K08HL173625
- This Project Grant award for $879,567.00, funded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research on lung injury in pediatric hematopoietic cell transplant (HCT) recipients. The research team at The Children's Hospital of Philadelphia (CHOP) will conduct a comprehensive characterization of the clinical, proteomic, and cell-free DNA biomarker profiles associated with the development of lung injury after HCT in...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $657,308 to The Children's Hospital of Philadelphia (CHOP) to conduct research on the CXCL12 signaling axis and its role in pulmonary arterial heterogeneity, development, and disease. The key objectives of this 12-month project are to: 1) define the spatiotemporal role of CXCL12 signaling in pulmonary vascular development, 2)...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $594,583 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Children's Hospital of Philadelphia (CHOP) Research Institute. The grant supports research to investigate the mechanisms regulating the development, expansion, and decline of neonatal lung myofibroblasts and their role in alveologenesis. Key objectives include utilizing a novel murine model to study myofibroblast lineage, characterize...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 - Cardiovascular Diseases Research provides $750,162 to The Children's Hospital of Philadelphia (CHOP) to conduct research aimed at understanding the role of lymphatic dysfunction in the development of post-lung transplant bronchiolitis obliterans syndrome (BOS), a serious complication. The research project will use murine models to investigate the mechanisms of lymphatic vascular function after...
- The National Heart, Lung, and Blood Institute (NHLBI), a division of the National Institutes of Health (NIH), awarded a $189,000 Project Grant under CFDA #93.837 Cardiovascular Diseases Research program to the University of Colorado-Denver. The 2-year grant, with a period of performance from September 15, 2025 to August 31, 2027, will support research to investigate the role of outdoor air pollution and environmental allergens in driving treatment response in children with acute asthma...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $180,174 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Children's Hospital of Philadelphia Research Institute. The grant will fund a study to develop a framework for designing the next generation of pediatric acute respiratory distress syndrome (ARDS) clinical trials. Key objectives include: 1) Comparing heterogeneity of treatment effect (HTE) analysis methodologies in a trial of pediatric...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $629,498 to The Trustees of the University of Pennsylvania (UEI GM1XX56LEP58) to conduct research aimed at deciphering the molecular mechanisms underlying pediatric interstitial lung disease (CHILD). The key objectives are to: Interrogate the anomalous development of the lung epithelium in CHILD by defining the impact of a specific SFTPC gene mutation on alveolar...
- This Project Grant award for $445,000.00 was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The funding supports research conducted by The Children's Hospital of Philadelphia (CHOP) to study the role of neutrophil extracellular traps (NETs) in inflammatory and thrombotic diseases. The project aims to characterize the role of NETs in immune homeostasis, determine the mechanisms by which NET stabilization...
- The Children's Hospital of Philadelphia (CHOP) has been awarded a $1,029,350 project grant by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct a study titled "Cardiometabolic Risk and Comorbidities in Adults with Down Syndrome - Electronic Health Record Examination (CASCADE)". The study aims to: Describe the prevalence of type 2 diabetes, dyslipidemia, hypertension, and obstructive sleep apnea, as well as quantify HbA1c and lipid...
- This federal Project Grant award, worth $809,162.00, was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to The Children's Hospital Corporation, doing business as Boston Children's Hospital, located in Massachusetts. The funding supports research to elucidate the differentiation pathways and functions of pulmonary ionocytes, a rare cell type in the human airway that expresses high levels of the cystic fibrosis transmembrane...
The Children's Hospital of Philadelphia (CHOP) received a $135,000 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) on July 16, 2025. The project aims to investigate how clinical, genetic, and social factors interact with short-term ambient air pollution (AAP) exposure to influence asthma exacerbations in pediatric patients. The research will also examine how these variables shape long-term lung function attainment in children genetically predisposed to AAP sensitivity. The project will leverage data science to develop predictive models for asthma outcomes, aligning with NHLBI's objective to open new frontiers in heart, lung, blood, and sleep research. The award supports research to be conducted by Dr. Jelte Kelchtermans at CHOP, with a scheduled completion date of June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $135.0k | 8/7/25 |