Project Grant K08EY037401
- This Project Grant award from the National Eye Institute's (NEI) Vision Research program, with a total funding amount of $618,088, aims to investigate the role of mitochondrial DNA (mtDNA) and the immune sensor protein ZBP1 in retinal neurodegeneration associated with glaucoma. The 4-year research project, running from February 1, 2025 to January 31, 2029, will be led by a multi-PI team at the University of Texas Medical Branch at Galveston. The key objectives are to test the hypothesis that...
- The National Eye Institute (NEI) awarded a $862,580 Project Grant under the Vision Research program (CFDA 93.867) to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The grant, titled "The Aging Eyes Study: Mitochondrial Dysfunction as a Driver of Age-Related Vision Loss," will run from Sep 30, 2024 to Sep 29, 2026. The project aims to identify the role of mitochondrial function and genetics in the etiology of aging-related eye diseases,...
- The National Eye Institute (NEI) awarded a $451,000 Project Grant under the Vision Research federal grant program (CFDA 93.867) to The Regents of the University of California, San Francisco (UCSF) to conduct a multimodal characterization of a novel inherited mouse model of glaucoma. The research aims to evaluate structural and functional changes in the mouse model, including axonal degeneration, retinal ganglion cell loss, dendritic changes, and neuroinflammatory responses. It will also identify...
- This Project Grant award for $679,159 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research on in vivo epigenetic reprogramming of retinal ganglion cells (RGCs) in aging mice with glaucoma. The research aims to identify new therapeutic targets for glaucoma that can protect and rejuvenate RGCs, which are specifically targeted and damaged in this disease leading to vision loss. The 4-year project, awarded to The Schepens Eye...
- This federal Project Grant award of $764,881 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research to investigate the role of advanced glycation end products (AGEs) in primary open-angle glaucoma (POAG). The overarching hypothesis is that the accumulation of AGEs in the trabecular meshwork promotes extracellular matrix remodeling and cell dysfunction, leading to increased outflow resistance and elevated intraocular pressure in POAG. The research project has two...
- This Project Grant award of $568,122.00, provided by the National Eye Institute (CFDA 93.867 - Vision Research), supports research at Baylor College of Medicine to unequivocally confirm the contribution of the neurovascular unit to glaucoma pathogenesis and identify endothelial cell-specific ligands with potential for neuroprotective therapy. The research aims to globally map ligands binding to ocular hypertension and healthy retinal cells, systematically identifying ocular...
- This federal Project Grant award of $234,000.00 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research to enhance stem cell restoration of intraocular pressure (IOP) homeostasis through senolytic treatments. The key goals are to study how senescent trabecular meshwork (TM) cells in glaucoma patients affect IOP regulation, and to explore whether clearing these senescent cells using senolytic drugs can improve the effectiveness of...
- This federal Project Grant award of $526,841 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) is supporting research by Vanderbilt University Medical Center to investigate the role of cyclic guanosine monophosphate (cGMP) signaling in glaucomatous neurodegeneration. The research aims to probe the mechanisms of retinal ganglion cell (RGC) degeneration in glaucoma, with the objective of identifying novel therapeutic targets to protect and potentially restore...
- The National Eye Institute (NEI), through its Vision Research federal grant program (CFDA 93.867), awarded a $661,635 project grant to The Research Foundation For The State University Of New York, doing business as SUNY Downstate Health Sciences University, to conduct research on elucidating the molecular changes in the extracellular matrix of the outflow pathway that regulate outflow facility in steroid-induced ocular hypertension and open-angle glaucoma. This 4-year project aims to determine...
- This federal Project Grant award of $240,713 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research into the role of the nuclear-encoded humanin isoform MTRNR2L1 in age-related macular degeneration (AMD). The awardee, The Research Foundation for the State University of New York (RF SUNY), will investigate whether MTRNR2L1 is a protein-coding gene or a long non-coding RNA, and examine its function in regulating mitochondrial activity and cell...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), provides $236,576 to the University of Miami to evaluate mitochondrial quality control in the outflow facility of the eye. The research project, led by Dr. Anh Pham, aims to identify mitochondrial dysfunction as a mechanism for developing ocular hypertension, a key risk factor for glaucoma. The 5-year project will utilize in vitro, ex vivo, and in vivo models to examine the relationship between mitochondrial health and outflow facility physiology, with the goal of establishing the foundation for future R01 research on mitochondrial quality control in the anterior segment of the eye. The findings from this award are expected to enhance the understanding of regulatory mechanisms controlling mitochondrial health and support the development of mitochondria-targeted therapies to improve intraocular pressure homeostasis.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $236.6k | 7/28/25 |