This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate the role of the VPS34 protein in the development and progression of pulmonary arterial hypertension (PAH). The $491,056.01 award, effective May 20, 2025 through April 30, 2028, aims to examine the regulation and function of VPS34 in PAH, determine its impact on proliferation and survival of pulmonary artery...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) Federal Grant Program provides $676,077 to Colorado State University (CSU) to study the impacts of fine particulate matter (PM2.5) air pollution on cardiovascular and respiratory health outcomes. The key products and services being delivered under this award include: Deploying a national network to measure the oxidative potential of PM2.5 samples, which...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, provides $893,525 to The Johns Hopkins University to implement and evaluate a multi-component intervention to protect lung health in Nepal. The 5-year project aims to reduce environmental risk factors like tobacco smoking and air pollution, as well as infectious risks, through community health worker-delivered education, household...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $705,279 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to Trustees of Boston University, doing business as Boston University Medical Campus, to investigate the mechanisms by which environmental pollutants impact the cardiovascular system. The 4-year project, starting January 1, 2025, will use a multidisciplinary approach including physiological studies, cellular imaging, RNA-sequencing, and mouse models to...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, is supporting research to investigate the genetic mechanisms underlying maladaptive respiratory responses to air pollution, specifically ozone (O3) exposure. The $671,165 award, spanning January 1, 2025 to October 31, 2029, will enable researchers at the University of North Carolina at Chapel Hill to: Profile the transcriptomes and...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, provides $704,105 to Brigham & Women's Hospital Inc. to study the impact of multiple long-term environmental exposures on the incidence of asthma. The research will leverage data from several large prospective cohort studies, including the Nurses' Health Studies and Health Professionals Follow-Up Study, to assess how factors like air...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, will support research investigating the impacts of environmental exposures, such as heat stress and wildfire smoke, on cardiovascular health over the life course. The $781,268 award to the University of Southern California will enable a longitudinal study of 400 young adults, analyzing how exposures from childhood to early adulthood...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, provides $702,364 to Yale University to conduct a nationwide analysis investigating the health impacts of fine particulate matter (PM2.5) exposure from different source sectors and fuel types. The key objectives are to: Estimate PM2.5 exposure by chemical components, source sectors, and fuel types across the continental U.S. from...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 - Cardiovascular Diseases Research provides $596,809 to Emory University to conduct research on the role of the mitochondrial protein MitoNEET in pulmonary hypertension (PH). The research aims to elucidate how MitoNEET regulates pulmonary artery smooth muscle cell function and mitochondrial bioenergetics, and to evaluate the potential of MitoNEET ligands as novel therapies for group 3 PH,...
This federal Project Grant award of $613,934 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research into the role of the aryl hydrocarbon receptor (AhR) signaling pathway in regulating airway smooth muscle responses during inflammation and asthma. The key objectives are to: 1) Determine the mechanisms of AhR expression and regulation in human airway smooth muscle under inflammatory conditions; 2) Investigate...