Project Grant K08DK147611
- The National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health within the Department of Health and Human Services, awarded Children's Research Institute $156,814 on August 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support Project Grant K08DK149197. The award funds research defining immunomodulatory mechanisms in autosomal recessive polycystic kidney disease (ARPKD), a severe...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Ann & Robert H Lurie Children's Hospital of Chicago $799,603 on August 10, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate intestinal embryonic macrophage dysfunction in necrotizing enterocolitis. The research examines how defective intestinal microvascular development contributes to necrotizing enterocolitis (NEC), a devastating disease in...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded The Children's Hospital Corporation, doing business as Boston Children's Hospital, $893,823 on February 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct genomically-driven discovery research on pediatric steroid-sensitive nephrotic syndrome (PSSNS). The award funds discovery and validation of genetic risk factors and biomarkers underlying PSSNS, a...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Ann & Robert H Lurie Children's Hospital of Chicago $786,725 on February 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of FMS-like tyrosine kinase-1 (FLT-1) in necrotizing enterocolitis development in premature infants. The research examines how defective intestinal microvascular development contributes to necrotizing enterocolitis, a...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Rush University Medical Center $749,087 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate sodium-independent mechanisms of edema in nephrotic syndrome. The project studies the role of circulating angiopoietin-like 4 (ANGPTL4), specifically its C-fragment, as a mediator of skin capillary endothelial permeability in nephrotic...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $826,174 to Cedars-Sinai Medical Center on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of the protein tyrosine phosphatase PTPRS in lupus nephritis and its therapeutic potential. The research addresses glomerulosclerosis and tubulo-interstitial fibrosis in chronic lupus nephritis, pathogenic aspects insufficiently addressed by...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Washington University $388,750 on April 23, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the structural and functional mechanisms of podocin in glomerular membrane organization and kidney disease. The research applies detergent-free, vesicle-based cryo-electron microscopy to determine the full-length structure of podocin at near-atomic resolution...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Southern California $599,437 on August 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to explore the immunomodulatory role of neuroendothelial cells (NECs) in kidney health and disease, with particular focus on lupus nephritis pathogenesis. The project will identify novel molecular and cellular mechanisms underlying lupus nephritis, the most...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Children's Hospital of Philadelphia Research Institute $1.868 million on June 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct integrative proteomics, metabolomics, and genomics analysis identifying mechanistic pathways of adverse outcomes in pediatric chronic kidney disease. The research leverages stored biosamples and existing data from over 1,100...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded The Children's Hospital Corporation, doing business as Boston Children's Hospital, $167,060 on August 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Project Grant K08DK143340). The award funds research on defective STAT3 signaling in very early-onset inflammatory bowel disease patients, with the objective of linking molecular pathways to precision-based...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Ann & Robert H Lurie Children's Hospital of Chicago $164,580 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Project Grant K08DK147611) to investigate immune-mediated mechanisms of tubulointerstitial injury in childhood nephrotic syndrome. The award funds basic research characterizing how dendritic cells and related inflammatory pathways contribute to tubulointerstitial injury and fibrosis progression in steroid-resistant nephrotic syndrome (SRNS), a leading cause of pediatric end-stage kidney disease. The research employs a mouse model of congenital nephrotic syndrome to isolate secondary effects of proteinuria and primary glomerular dysfunction, with focus on identifying targetable injury pathways that could enable development of treatments to slow renal fibrosis progression in affected children. Performance occurs in Chicago, Illinois through May 31, 2031. The program supports extramural basic and clinical biomedical research improving understanding of disease mechanisms and leading to improved prevention, diagnosis, and treatment of diabetes, digestive, and kidney diseases across NIDDK's programmatic areas.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $164.6k | 8/21/26 |