Project Grant K08DK140618
- This Project Grant award of $806,192 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to delineate how a deficiency in the ATP-binding cassette protein MRP9 causes injury to cholangiocytes, the cells that line the bile ducts, in chronic cholestatic liver diseases. The research is being conducted by the Children's Hospital Medical...
- This federal Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351) provides $246,000.00 to The Regents of the University of California, San Francisco (UCSF) to characterize a novel mouse model that links sphingolipid metabolism to multi-organ fibrosis. The research aims to elucidate the factors that cause fibrosis to progress from a self-limited response to a chronic, lethal condition, and identify endogenous factors that may...
- This $1,558,188 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate how changes in transcription factor and heterochromatin states in embryos and adult livers impact hepatocyte development, homeostasis, and regeneration. The project, led by researchers at the University of Pennsylvania, will utilize advanced...
- This Project Grant award for $163,825 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research on the role of AXL signaling in intestinal fibrosis associated with Crohn's disease. The research, led by Dr. Steiner at the University of Colorado-Denver, aims to unravel the mechanisms of AXL signaling and how it contributes to intestinal responses and fibrosis, with the ultimate goal of...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research provides $115,288 to the University of North Carolina at Chapel Hill (UNC-CH) to support research on transcriptional regulation of mitochondrial metabolism in human intestinal stem cells. The principal investigator, Dr. Joseph Burclaff, is mentored by Dr. Scott Magness. The project aims to determine how the...
- This federal Project Grant award of $2,076,999 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research on the role of mitochondrial dysfunction in Paneth cells and its relationship to inflammatory bowel diseases, including Crohn's disease. The principal investigator will use a mouse model with Paneth cell-specific deletion of the mitochondrial chaperone protein Prohibitin 1 to...
- This Project Grant award of $215,700 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research program) is supporting research at Baylor College of Medicine to investigate the use of the antibiotic rifaximin to reduce bacterial-derived inflammation and subsequent liver fibrosis in neonatal cholestasis, a leading cause of pediatric liver transplants. The research aims to explore whether suppressing gut...
- This Project Grant award of $1,170,271 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research program) aims to investigate the mechanisms by which the X-box binding protein 1 (XBP1) pathway regulates bile acid metabolism during cholestatic liver disorders. The central hypothesis is that hepatic XBP1 activation reduces bile acid synthesis and regulates bile acid metabolism by transcriptionally...
- This federal Project Grant award for $603,632, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research, aims to define the role of the PLA2G12B protein in regulating the assembly, plasma levels, metabolism, and cardiovascular disease risk of apolipoprotein B (apoB)-containing lipoproteins. The primary grantee, The Johns Hopkins University, will leverage novel tools to investigate how...
- This Project Grant award of $234,000 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at the University of Colorado-Denver to investigate the role of the Aiolos transcriptional regulator in the pathogenesis of inflammatory bowel disease. The researchers aim to utilize CRISPR-Cas9 genome editing to examine how Aiolos regulates T cell...
This federal Project Grant award of $176,094 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) will support research to investigate the role of the transcription factor RUNX1 in biliary fibrosis, a key characteristic of primary sclerosing cholangitis (PSC) and primary biliary cholangitis. The research aims to elucidate how RUNX1 coordinates transcriptomic and lipidomic programs in cholangiocytes that stimulate immune cell signaling and fibrosis. The project will utilize genetic deletion of RUNX1 in cholangiocytes in mouse models to study the effects on immune cell recruitment and activation, as well as evaluate the potential of the SCD1 inhibitor Aramchol as a therapeutic target. This 5-year project, with a start date of September 15, 2025, will be conducted by researchers at Virginia Commonwealth University.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $176.1k | 9/11/25 |