Project Grant R03DK144347
- This Project Grant award of $806,192 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to delineate how a deficiency in the ATP-binding cassette protein MRP9 causes injury to cholangiocytes, the cells that line the bile ducts, in chronic cholestatic liver diseases. The research is being conducted by the Children's Hospital Medical...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $3,233,421 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Yale University. The grant, with a performance period of September 1, 2025 to August 31, 2029, will support research to investigate the role of neutrophils in the pathogenesis of cholangiopathies - chronic liver diseases affecting bile ducts. The research aims to elucidate the...
- This Project Grant award of $250,056.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is supporting a pilot study at the University of North Carolina at Chapel Hill (UNC-CH) to evaluate the feasibility, safety, and tolerability of using the antibiotic rifaximin for the secondary prevention of pouchitis recurrence. The study aims to demonstrate the feasibility of...
- This Project Grant award of $1,982,628.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to develop advanced methods for detecting liver fibrosis and creating a predictive diagnostic model for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in primary care settings. The project aims to improve identification of...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $441,375 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Children's Hospital Medical Center (UEI JZD1HLM2ZU83) to conduct research on the "Transcriptional Mechanisms of Chronic Inflammation in Genetically Diverse Tissue Macrophages." The project will focus on understanding the genetic factors and regulatory mechanisms that contribute to the development of metabolic...
- This Project Grant award of $427,625 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research on the development of the probiotic bacterium Limosilactobacillus reuteri (L. reuteri) as a therapeutic delivery vehicle. The key objectives are to create carbohydrate-regulated gene expression systems for recombinant protein production in L. reuteri, without requiring antibiotic resistance markers or inducer peptides. This...
- This federal Project Grant award of $122,454, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research investigating the role of the GIMAP5 gene in maintaining liver homeostasis. The primary recipient, Yale University, is conducting studies to determine how loss of function in the GIMAP5 gene leads to capillarization and dedifferentiation of liver...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $2,999,512 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The University of Texas Southwestern Medical Center, doing business as Southwestern Medical School. This 4-year award, starting on September 1, 2025, will support research to investigate the regulation of mitochondrial health in mammalian livers, with a focus on understanding the...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $232,073 to Brown University to conduct research on alleviating antibiotic-induced gut dysbiosis by restoring small intestinal bile acid metabolism. The key objectives are to determine the role of bile acid metabolism in antibiotic-induced gut dysbiosis and evaluate the efficacy of bile acid restoration to...
- This $626,429 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports research at Baylor College of Medicine to investigate the role of the carbohydrate responsive element binding protein (CHREBP) and its isoforms in liver metabolism and metabolic diseases. The key objectives are to define the specific functions of the CHREBP-beta isoform in a model where CHREBP-alpha has been removed, as well as explore the dose-dependent effects of...
This Project Grant award of $215,700 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research program) is supporting research at Baylor College of Medicine to investigate the use of the antibiotic rifaximin to reduce bacterial-derived inflammation and subsequent liver fibrosis in neonatal cholestasis, a leading cause of pediatric liver transplants. The research aims to explore whether suppressing gut bacteria-derived endotoxins can mitigate fibrosis progression in biliary atresia patients, offering a potential safer alternative to high-potency antibiotics that risk drug-induced liver injury. The award period runs from August 1, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $215.7k | 7/30/25 |