Project Grant K08AR086331
- Federal Project Grant Award Summary Albert Einstein College of Medicine received a $177,984 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective June 1, 2026 through May 31, 2031. The research project, titled "Intrarenal Complement Activation as a Marker of Kidney Injury and Treatment Response in Lupus Nephritis," will be conducted at...
- Project Grant Summary Rutgers The State University of New Jersey, Robert Wood Johnson Health Sciences (RBHS)-School of Nursing received a $637,018 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), awarded August 7, 2025, with completion targeted for June 30, 2030. The grant funds basic and translational research investigating the role of natural killer (NK)...
- This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $115,414 to the Beckman Research Institute of the City of Hope to conduct research aimed at concurrently eradicating pathogenic plasma cells and their precursors in systemic lupus erythematosus (SLE). The award, which runs from September 2024 to August 2026, will support two specific aims: 1) determining the effect of knockdown of the...
- Federal Project Grant Award Summary Brigham and Women's Hospital, in collaboration with Massachusetts General Hospital (MGH), received a $729,120 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded March 1, 2026, with completion targeted for December 31, 2028. This pilot and feasibility randomized controlled trial investigates the safety, tolerability,...
- Federal Project Grant Award Summary Mayo Clinic received a $127,273 project grant award dated September 5, 2025, from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research project, extending through August 31, 2027, investigates the role of TFEB (a transcription factor) in regulating age-associated B cells (ABCs) and their contribution to systemic autoimmunity, with...
- Federal Project Grant Award Summary This five-year Career Development Award, administered by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to elucidate the mechanisms by which retroelements contribute to systemic lupus erythematosus (SLE) autoimmunity. Awarded to Yale University on May 15, 2026, with a total obligation of $170,964.00 and a completion date...
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded $158,609 to the University of Alabama at Birmingham under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) on April 1, 2026, for a five-year project period concluding March 31, 2031. The research focuses on investigating resident memory T cells (TRMs) in kidney disease pathology during autoimmunity, specifically examining how TRMs...
- This Project Grant award of $405,350.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research aims to characterize lipid droplets in macrophage subsets and determine if manipulating lipid droplet content can shift macrophage function, with the goal of uncovering new therapeutic targets for systemic lupus erythematosus (SLE). The award recipient is The...
- This $375,100 federal Project Grant award was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant funds a study to investigate the interplay between nucleic-acid-dependent phase separation and immune responses against cyclic GMP-AMP synthase (cGAS) in systemic lupus erythematosus (SLE). The research aims to determine how changes in the biophysical...
- Federal Grant Award Summary The University of Washington received a $412,569 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), awarded May 1, 2026, with completion scheduled for April 30, 2028. This research project will develop and validate biomarker assays to measure inflammatory modes of programmed cell death—specifically pyroptosis, necroptosis, and...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) provides $172,560 in federal funding to The Trustees of Columbia University in the City of New York to conduct translational research investigating the role of SAP (SLAM-Associated Protein) positive T cells in lupus nephritis. The five-year research project, which commenced June 1, 2026 and concludes May 31, 2031, will generate scientific knowledge regarding immune mechanisms underlying lupus nephritis progression, with the ultimate goal of identifying novel biomarkers and therapeutic targets for this serious kidney manifestation of systemic lupus erythematosus. The research deliverables include characterization of SAP+ T cell clonal proliferation patterns and signaling pathways using single-cell RNA sequencing with T cell receptor sequencing, spatial transcriptomic mapping of SAP+ T cells within kidney biopsy samples, and mechanistic studies of SLAMF6-SAP signaling in effector T cell survival and differentiation. The project is designed to advance fundamental understanding of tubulointerstitial inflammation—a major driver of tubular atrophy and progression to end-stage kidney disease in lupus nephritis patients—with anticipated publication of peer-reviewed research findings and identification of potential therapeutic interventions targeting SAP-specific regulatory networks in rheumatic kidney disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 5/5/26 | ||
| Not listed | $172.6k | 4/29/26 |