Project Grant K08AI187710
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $555,774.00 to the University of Alabama at Birmingham (UAB) over a 5-year period starting November 19, 2024. The award supports research to investigate the role of the aryl hydrocarbon receptor (AhR) pathway in regulating the development of T-bet+ B cells, which are implicated in the pathogenesis of systemic lupus...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $501,011.00 to the University of North Carolina at Chapel Hill to conduct research on biodegradable polymeric microparticles comprised of acetalated dextran and their ability to induce immune tolerance. The goal is to develop an antigen-specific tolerance therapy for autoimmune diseases, an alternative to general...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $807,799 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to the University of Chicago. The grant, which runs from Jul 15, 2025 to Jun 30, 2030, supports research to investigate the role of a specialized subset of regulatory T cells in controlling self-reactive B cells and the production of autoantibodies. The research aims to identify these B cell-dependent...
- This Project Grant award for $300,000 from the Department of Health and Human Services' National Institutes of Health (CFDA 93.310 Trans-NIH Research Support) to Brigham & Women's Hospital Inc. (a subsidiary of Partners Healthcare System) supports research on the role of activated neutrophils and T cells in the pathogenesis of systemic lupus erythematosus (SLE), lupus nephritis, and vasculitis. The research aims to investigate how immune cell abnormalities, specifically the generation of...
- This Project Grant award of $423,500 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to develop novel antibodies that target autoreactive B cells as a potential therapeutic approach for treating systemic lupus erythematosus (SLE) patients, particularly among the African American population. The key objectives are to determine the autoantigen specificity and clinical relevance of...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to North Carolina State University for $470,989, with a project period from December 2024 to November 2029. The grant aims to systematically identify functional single nucleotide polymorphisms (SNPs) in the Fc gamma receptor (FcR) locus and determine their impact on antibody-mediated functions such as antibody-dependent cellular...
- This Project Grant award of $225,953 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Program (CFDA 93.855), supports research to define and characterize human B cells that are reactive to foreign glycans, or xenoglycans. The research aims to determine if xenoglycan-reactive B cells exist as a distinct subset compared to protein-reactive B cells, and to examine the molecular and functional features of these...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $153,512 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Leland Stanford Junior University. The grant will fund research to characterize the renal immune microenvironment in antibody-mediated rejection (ABMR) of kidney transplants in order to develop improved diagnostics and predict treatment response. The research will utilize advanced imaging mass cytometry to profile...
- This $556,843 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to advance the understanding of the extrafollicular (EF) B cell response and its role in immunity. The project aims to investigate how the EF response, which produces rapid expansion and differentiation of plasma cells, differs from the more well-studied germinal center (GC) response. Key focus...
- This Project Grant award of $634,984 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of a specific B cell subset, termed BND2, in the autoimmune disorder type 1 diabetes (T1D). The research aims to: 1) elucidate the mechanism by which these insulin-reactive BND2 cells become activated and break anergy, 2) determine their fate and function as antigen-presenting...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $198,032 to the University of North Carolina at Chapel Hill (UNC-CH) to conduct research aimed at identifying and targeting autoantigen-specific B cells in ANCA vasculitis, an autoimmune kidney disease. The goal is to define immunological remission based on the underlying B cell receptors (BCRs) and the immunophenotype of autoantigen-specific B cells, with the intent of developing therapies to remove these autoantigen-specific B cells as a proof of concept. This 5-year project, starting on September 1, 2025, will leverage UNC-CH's established cohort of ANCA vasculitis patients to advance understanding of the disease and explore novel treatment approaches.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $198.0k | 8/26/25 |