Project Grant R21AI184073

Award Date 8/6/24
Completion Date 7/31/26
Dollars Obligated $251K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
California, USA
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  1. Utilizing an ex vivo tissue model to test the effects of a chimeric CD127 monoclonal antibody (4A10) on inhibiting IL-7 signaling and mediating antibody-dependent cell-mediated cytotoxicity/phagocytosis against HIV reservoir cells expressing CD127.

  2. Using a humanized mouse model to investigate the impact of 4A10 on HIV persistence, including its ability to lead to ART-free HIV remission when administered to mice on stable ART or during ART initiation.

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