Project Grant K08AG088493
- This $430,101 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Vanderbilt University Medical Center (VUMC) will fund research to identify new genes and genetic variants responsible for telomere shortening, telomere disease risk, and premature aging. The project aims to determine the genetic basis of telomere shortening across diverse tissues, explore the phenome-wide consequences of telomere length using large-scale biobank data, and identify...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $245,434 to Wake Forest University Health Sciences to conduct research on preserving muscle and bone health in older adults undergoing weight loss interventions. The 2.5-year project aims to develop automated analysis techniques to measure changes in muscle quantity and quality, as well as bone strength, using computed tomography (CT) scans collected as part of an ongoing clinical trial....
- The National Institute on Aging (NIA) awarded a $2,552,654.85 project grant to Vanderbilt University Medical Center under the Aging Research federal grant program (CFDA 93.866) on January 1, 2025. This grant supports efforts to systematically screen and validate drug repurposing candidates for Alzheimer's disease and related dementias (AD/ADRD). The project aims to integrate genetics, transcriptomics, literature, and clinical data with advanced informatic technologies and computational...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,531,593.00 to Vanderbilt University Medical Center to conduct research on the role of sex-specific genetic factors in the development and progression of cerebrovascular disease (CVD) within the Alzheimer's disease (AD)-affected brain. The research aims to: 1) identify sex-specific genetic markers of autopsy measures of brain vessel disease, 2) identify sex-specific genetic markers of...
- This $481,250 Project Grant was awarded by the National Institute on Aging (CFDA 93.866 Aging Research) to Vanderbilt University Medical Center (VUMC) on September 1, 2024. The award supports the development of an innovative, non-invasive MRI imaging technique to assess membrane lipid properties in Alzheimer's disease (AD). The key objectives are to: 1) verify the relationship between the MRI nuclear Overhauser enhancement (NOE) signal and lipid properties using reconstituted phospholipid...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $166,488 Project Grant to the University of California, Davis to investigate the role of hypoxia-inducible factor-2a (HIF-2a) signaling in age-induced bone loss. The project aims to identify mechanisms underlying bone deterioration with aging and develop novel therapies to reverse age-related osteoporotic bone loss and improve fracture resistance. The project period runs from December...
- This $146,070 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate how the accumulation of senescent cells and their secretory phenotypes impact osteocyte mechanobiology in a 3D bone-mimicking microenvironment. The goals are to: (1) acquire experimental skills and career training to expand the researcher's program into cellular aging/senescence and molecular biology; (2) investigate how local vs. systemic senescent cells and...
- The National Institute of General Medical Sciences (NIGMS) awarded a $300,892 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Vanderbilt University to computationally assess the impact of aging-related oxidative stress on the human proteome using a novel deep learning methodology. The project aims to build predictors for oxidation modification sites on proteins by first constructing a deep learning-based atomic protein structure embedding method. This...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,126,515 to Trustees of Indiana University in Indianapolis, IN to conduct research aimed at understanding how the L-BAIBA/FGF23 axis, an interaction between muscle and bone, can be targeted to enhance musculoskeletal health and resilience in aging populations. The research seeks to elucidate the mechanisms by which this muscle-bone signaling pathway becomes dysregulated with age, leading to...
- This federal Project Grant award for $1,249,147.00 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The grant is a collaborative effort between Epicypher, Inc., a biotechnology company in Durham, North Carolina, and Dr. Nicolas Young of Baylor College of Medicine to develop a novel platform called AgingPTM for studying aging-associated combinatorial histone post-translational modifications (ACPTMs) in tissue. This platform is intended to...
The Vanderbilt University Medical Center was awarded a $149,889 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) on September 1, 2025. The grant supports a discovery-focused effort to identify epigenetic factors that cause early onset osteoporosis associated with imaging findings on computed tomography (CT) scans. The research aims to refine and validate deep learning approaches to measure bone mineral density from opportunistically-acquired CT scans, and explore the connection between epigenetic modification of genes and imaged bone findings. This project represents a crucial step in understanding the mechanistic association between epigenetic bone age, frailty measures, and bone imaging studies using novel artificial intelligence techniques. The research is expected to be completed by May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $149.9k | 8/26/25 |