Project Grant K01HL179256
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $108,978 Project Grant under CFDA program 93.837 - Cardiovascular Diseases Research to President and Fellows of Harvard College to conduct research on "Mechanisms of Regenerative Decline in Aged Alveolar Type 2 Cells". The research aims to investigate how aging impacts the regenerative capacity of alveolar type 2 cells, which play a critical role in maintaining the lung's gas exchange surface. The grant project will run...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $140,403 to the President and Fellows of Harvard College, Harvard T.H. Chan School of Public Health, to develop and apply new multi-omic network methods for mapping molecular trajectories of age-related lung diseases, specifically chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). The 5-year project aims to elucidate the...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research into the role of the long non-coding RNA SALTE1 in vascular aging and heart failure with preserved ejection fraction (HFPEF). The $708,266 award to The General Hospital Corporation (doing business as Massachusetts General Hospital) will fund a 4-year research project to determine the role of SALTE1 in vascular aging and HFPEF, and examine the underlying...
- This $165,364 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research by the Broad Institute, Inc. to identify novel contextual and genomic blood pressure (BP) measures to enhance cardiovascular disease (CVD) prediction and management in young adults aged 18-39. The key products and services to be delivered under this 2-year award include: Identifying novel ambulatory BP patterns capturing...
- This federal Project Grant award of $812,189 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to better understand changes in the pulmonary vasculature and their relationship to lung parenchyma changes using advanced CT imaging in patients with pulmonary arterial hypertension (PAH) and chronic obstructive pulmonary disease (COPD). The primary recipient, Brigham & Women's Hospital, will leverage...
- This federal Project Grant award of $710,302, provided by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), supports research to investigate the origin and characterize the functional state of lung interstitial neutrophils (LINs), a specialized subpopulation of neutrophils within the lung. The project aims to advance the understanding of the function, fate, pathophysiological role, and therapeutic potential of LINs, which play a key role in bacterial...
- This $1,031,595 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The awardee, Dana-Farber Cancer Institute, will define the landscape and mechanisms of protein redox regulation during aging. Specifically, the Institute will systematically map cysteine oxidation networks in mouse tissues to determine their role in coordinating protein complex assemblies relevant to age-related...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $676,748 to Brigham & Women's Hospital (a subsidiary of Partners Healthcare System) to conduct research on extending neutrophil survival in neutropenia-related pneumonia. The goal is to explore an alternative strategy for treating and preventing this type of pneumonia by increasing the lifespan of neutrophils in the lungs of neutropenic patients. The...
- This $1,526,628 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will support the development of artificial intelligence (AI) methods to analyze echocardiography data and identify biomarkers of cardiovascular aging. The goal is to use AI to predict biological cardiovascular age, discern accelerated versus delayed cardiovascular aging trajectories, and uncover key risk factors that contribute to age-related cardiovascular...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $639,740.00 to investigate the role of the CD38 enzyme in the development of chronic lung conditions following viral infections like COVID-19. The research aims to explore how targeting CD38 on CD8 tissue resident memory (TRM) cells could mitigate age-associated lung fibrosis after viral pneumonia. The award, effective December 15, 2024 through November 30, 2029, will support the lead researcher...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $177,120 to Brigham & Women's Hospital Inc. (a subsidiary of Partners Healthcare System Incorporated) to characterize biological aging processes and develop multi-omic ageotypes to understand the molecular mechanisms linking aging to chronic heart and lung diseases. The key objectives of this 5-year project are to: 1) develop and validate multi-omic ageotypes using metabolomics and epigenetics data in two large cohorts with electronic medical records, 2) identify molecular drivers that contribute to each ageotype, particularly in relation to heart and lung diseases, and 3) elucidate the relationship between ageotypes and chronic cardiovascular and pulmonary conditions. Through personalized approaches for different ageotypes, the project aims to improve treatment and potentially delay or prevent the onset of chronic heart and lung diseases, with the goal of having a significant public health impact.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $177.1k | 9/18/25 |