Project Grant K01HL175220
Award Date
9/17/24
Completion Date
9/30/29
Dollars Obligated
$173K
Federal Agency
National Heart Lung and Blood Institute
Awardee
Yale Univ (FL6GV84CKN57)
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
New Haven, CT 06510, USA
Similar Awards
The National Heart, Lung, and Blood Institute awarded a $1,371,242 Project Grant under the Cardiovascular Diseases Research (CFDA 93.837) program to The University of Texas Rio Grande Valley. The 4-year grant, which runs from Sep 1, 2024 to Jun 30, 2028, will fund research to identify genetic and environmental factors underlying the high incidence of factor VIII inhibitors (FEI) in hemophilia A patients of Mexican ancestry. Key project goals include extensively characterizing a cohort of 200...
This federal Project Grant award, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to externally validate and refine an agent-based model that simulates the effects of implementation strategies on improving hypertension care guidelines for persons with HIV in Indiana. The total funding amount for this 2-year project is $118,875, with an award date of September 1, 2024. The key objectives are to: 1) externally...
This Project Grant award, valued at $607,535, was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports research to investigate the effects of the breakdown product hemin on the pulmonary endothelium and its contribution to the pulmonary complications of sickle cell disease, including acute chest syndrome and pulmonary hypertension. The research aims to evaluate the specific effects of...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $252,285 to St. Jude Children's Research Hospital Inc. to support a 5-year training program focused on basic and translational research in pediatric classical hematology. The program will support three postdoctoral fellows conducting hypothesis-driven research to elucidate the mechanisms of non-malignant blood diseases and uncover new therapeutic targets. The...
This federal Project Grant award of $771,902 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support research to examine the effects of HIV-associated extracellular vesicles (EVs) containing the protein NEF on macrophage heterogeneity and function, and their contribution to the formation of high-risk atherosclerotic plaques in people living with HIV. The research aims to identify novel mechanisms and therapeutic targets related to impaired...
This Project Grant award of $734,607 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to elucidate the key endothelial mechanisms that direct hematopoietic stem cells (HSCs) across the blood vessel wall and into their niche. The research, conducted by Boston Medical Center Corporation, will use high-resolution live cell imaging, structure-function studies, and in vivo proximity-dependent biotinylation in zebrafish to define the endothelial...
This federal Project Grant award for $641,544 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support the development of enhanced machine learning tools to analyze complex biomedical data related to heart, lung, blood, and sleep (HLBS) disorders. The key objectives are to: 1) propose novel machine learning methods to reveal causal relationships between clinical features and health/disease outcomes, 2) build deep learning frameworks to...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $1,276,908 in funding to Bloodworks (Puget Sound Blood Center and Program) from March 1, 2025 to February 28, 2032. The grant supports advanced molecular and translational research on the mechanisms of von Willebrand disease and sickle cell disease, which both involve the von Willebrand factor protein. The research aims to...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $291,848 to Tulane University to evaluate the impact of loss of heterozygosity on localized arteriovenous malformation (AVM) formation in hereditary hemorrhagic telangiectasia (HHT). The project aims to develop an HHT mouse model of SMAD4 loss of heterozygosity, compare it to previous SMAD4 knockout models, and explore the role of localized loss of function...
This federal Project Grant award, totaling $753,813 and provided by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research to develop novel machine learning techniques for predicting cardiovascular outcomes in patients with clonal hematopoiesis of indeterminate potential (CHIP). The key goals are to use cardiac MRI imaging and genomic data to: 1) Develop a machine learning model to accurately identify CHIP patients and predict their risk...