This $163,080 five-year Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 Cardiovascular Diseases Research program will support research conducted by the Ann & Robert H. Lurie Children's Hospital of Chicago to study the regulatory T cell response in children with severe viral pneumonia.
The specific aims of the project are to: 1) determine whether juvenile regulatory T cells have impaired reparative functions during severe viral pneumonia, 2)...
This $644,365 Project Grant awarded by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to identify novel strategies to mitigate cardiac damage and dysfunction following invasive pneumococcal disease.
The key research objectives include: 1) Determining the role of the S100A8/9-NLRP3-IL-1β signaling pathway in mediating excessive cardiac inflammation and adverse remodeling following pneumococcal infection, and 2)...
This federal Project Grant award of $145,910.00 from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will support a five-year observational study at the Children's Hospital of Philadelphia (CHOP). The study aims to assess myocardial dysfunction and inflammation in 200 critically ill children after cardiac arrest. The research will leverage advanced echocardiographic imaging techniques and biomarker analysis to examine...
The National Heart, Lung, and Blood Institute (NHLBI) has awarded a $2,070,206 Project Grant (CFDA 93.837 Cardiovascular Diseases Research) to the Ann & Robert H. Lurie Children's Hospital of Chicago to conduct the "LONG-TERM ENDOTYPES OF PREMATURITY ASSOCIATED RESPIRATORY DISEASE (LEOPARD)" study. This 4-year project aims to leverage existing genetic and longitudinal clinical data from approximately 2,000 former preterm infants to characterize the long-term respiratory disease...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to identify the role of myeloid-derived suppressor cells (MDSC) in modulating disease severity in children with viral lower respiratory tract infections. The $180,199 award, effective from September 1, 2024 to August 31, 2029, will enable the Research Institute at Nationwide Children's Hospital to characterize MDSC and...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $819,860 to St. Jude Children's Research Hospital Inc. to develop and validate race-specific cardiomyopathy risk prediction models for African American survivors of childhood cancer. The research aims to enhance clinical risk stratification by identifying influential predictors, developing novel risk algorithms, and evaluating the added value of genetic...
The University of Colorado-Denver received a $126,059 Project Grant from the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports a 5-year research project to investigate the systems biology of acute and chronic multi-organ failure in children with congenital heart disease (CHD).
Specifically, the research will utilize proximity extension assay technology to perform longitudinal measurement of the circulating proteome...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to validate the use of the end tidal alveolar dead space fraction (AVDSF) as a risk stratification marker for mortality in pediatric acute respiratory distress syndrome (ARDS). The $873,736 award to Children's Hospital Los Angeles aims to determine if AVDSF can identify heterogeneity in treatment effect for inhaled...
This federal Project Grant award, funded by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), aims to investigate how red blood cells (RBCs) contribute to inflammation and multi-organ dysfunction associated with cardiopulmonary bypass (CPB) procedures during pediatric heart surgeries. The $2,543,734 award to Seattle Children's Hospital, effective May 1, 2024 through April 30, 2028, will fund experiments to uncover the molecular mechanisms by which...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $173,609 Project Grant (CFDA 93.837 Cardiovascular Diseases Research) to The Washington University to develop and evaluate a personalized, AI-based clinical decision support (CDS) system to guide presurgical blood orders and improve perioperative blood management. The project aims to assess the feasibility and preliminary effectiveness of the S-PATH CDS tool, which estimates surgical transfusion risk, when embedded within the...