The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), awarded a $162,461 Project Grant under the Human Genome Research (CFDA 93.172) program to the University of Utah. The grant supports a 5-year (Sept 2024 - Aug 2029) research project titled "Integrated Multimodal Phenotyping of Zebrafish Models of Human Cognitive Disorders". The goal is to leverage advanced genome editing and single-cell sequencing techniques to rapidly generate and characterize zebrafish models of genetic disorders that impact human cognition. The research will systematically analyze the molecular, cellular, brain morphological, and behavioral features of these models to construct predictive machine learning models that can uncover connections between genetics, brain development, and cognitive outcomes. These models may yield new treatment strategies for various human cognitive disorders. The University of Utah will conduct this comprehensive multimodal phenotyping research through an intensive training plan that will transition the principal investigator from an experimental biology background to become a leader in functional genomics and data informatics.
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