Project Grant K01ES036552

Award Date 7/20/24
Completion Date 6/30/27
Dollars Obligated $528K
Federal Grant Program
93.113
Assistance Type
Project Grant
Place of Performance
San Diego, CA 92182, USA
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The objective of this research project is to investigate the biological mechanisms by which the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine (DCVC) disrupts placental function and contributes to adverse birth outcomes such as low birth weight and restricted fetal growth. Key elements of the research include: 1) identifying placental cell types vulnerable to DCVC exposure using single-nucleus RNA sequencing, 2) examining DCVC effects on mitochondrial energetics of syncytiotrophoblasts, and 3) determining if DCVC affects placental barrier function. The findings are expected to inform policy makers and clinicians about the role of environmental contaminants in pregnancy complications, with the goal of improving maternal and fetal health outcomes.

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