Project Grant K01DK144653
- This federal Project Grant award of $737,034.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The goal of this 5-year research project, with a start date of September 1, 2025, is to identify new regulatory inputs that control the biosynthesis of coenzyme A (CoA) in response to the metabolic state of cells and tissues, especially the kidney and liver. The...
- This $2,971,227 federal Project Grant, awarded on September 4, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of fatty acids in regulating cellular metabolism and protein synthesis in the context of fasting, inflammation, and metabolic diseases. The research aims to uncover novel signaling pathways through which fatty...
- This $409,375 federal Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research at The Johns Hopkins University to understand the contribution of hepatic fatty acid oxidation to hepatic and systemic metabolic homeostasis. The research aims to describe novel requirements and signaling roles of hepatic fatty acid oxidation that...
- This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research focused on understanding the mechanisms that regulate lipid flux in cells and animals, and how crosstalk between gut immune cells and the absorptive epithelium impacts metabolic disease. The $761,399 award, effective September 1, 2025 through June 30, 2030, will...
- This $2,638,760.00 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research aims to investigate a novel mechanism involving the metabolite rhodoquinone (RQ) and its potential role in improving mitochondrial function and mitigating metabolic diseases caused by obesity. Specifically, the project will elucidate how the RQ/fumarate...
- This $128,286 Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research into the mechanisms of renal lipotoxicity and its contribution to the development of chronic kidney disease (CKD). The principal investigator will investigate the protective role of the FAF2 gene knockout in mitigating palmitate-induced lipotoxicity in...
- This $1,558,188 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate how changes in transcription factor and heterochromatin states in embryos and adult livers impact hepatocyte development, homeostasis, and regeneration. The project, led by researchers at the University of Pennsylvania, will utilize advanced...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) is providing $179,000.00 to St. John's University in New York to investigate the physiological role of 16α-hydroxylated bile acids in regulating energy intake and hepatic lipid metabolism. The project aims to determine how 16α-hydroxylated bile acids affect these metabolic processes and enhance the synthesis of...
- This $233,250 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to understand how macrophage branched chain amino acid (BCAA) metabolism contributes to obesity-related metabolic dysfunction. The project, led by The Washington University, will investigate the role of the enzyme protein phosphatase 1K (PPM1K) in regulating macrophage BCAA metabolism and...
- This $562,499 project grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 supports research on bile acid-mediated regulation of food intake. The grantee, St. John's University, New York, will examine the hypophagic mechanism of 16α-hydroxylated bile acids, their interaction with N-acyl phosphatidylethanolamine phospholipase D, and the effect of enzymes producing 16α-hydroxylated bile acids on modifying bile acid composition in mice....
This federal Project Grant award of $159,775.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to elucidate the regulation of choline metabolism under obese conditions and its impact on metabolic health. Key activities include in vivo flux analysis to map the fate of choline in the livers of control and choline carrier knockout mice, as well as studies on the epigenetic modifications dependent on choline metabolism. The research aims to reveal novel mechanisms for treating metabolic-associated liver dysfunction. The award period runs from September 15, 2025 to August 31, 2030 and the work will be performed at the Regents of the University of Minnesota.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $159.8k | 9/12/25 |