Project Grant R16DK147915
- This $562,499 project grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 supports research on bile acid-mediated regulation of food intake. The grantee, St. John's University, New York, will examine the hypophagic mechanism of 16α-hydroxylated bile acids, their interaction with N-acyl phosphatidylethanolamine phospholipase D, and the effect of enzymes producing 16α-hydroxylated bile acids on modifying bile acid composition in mice....
- The U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $222,500 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Beckman Research Institute of the City of Hope. The grant supports research to understand how conjugated bile acids regulate metabolism after bariatric surgery, with the goal of developing safer and more affordable treatments for obesity and fatty liver disease. Key activities include...
- This federal Project Grant award of $159,775.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to elucidate the regulation of choline metabolism under obese conditions and its impact on metabolic health. Key activities include in vivo flux analysis to map the fate of choline in the livers of control and choline carrier knockout...
- This $2,971,227 federal Project Grant, awarded on September 4, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of fatty acids in regulating cellular metabolism and protein synthesis in the context of fasting, inflammation, and metabolic diseases. The research aims to uncover novel signaling pathways through which fatty...
- This federal Project Grant award for $603,632, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research, aims to define the role of the PLA2G12B protein in regulating the assembly, plasma levels, metabolism, and cardiovascular disease risk of apolipoprotein B (apoB)-containing lipoproteins. The primary grantee, The Johns Hopkins University, will leverage novel tools to investigate how...
- This $2,638,760.00 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research aims to investigate a novel mechanism involving the metabolite rhodoquinone (RQ) and its potential role in improving mitochondrial function and mitigating metabolic diseases caused by obesity. Specifically, the project will elucidate how the RQ/fumarate...
- This federal Project Grant award of $737,034.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The goal of this 5-year research project, with a start date of September 1, 2025, is to identify new regulatory inputs that control the biosynthesis of coenzyme A (CoA) in response to the metabolic state of cells and tissues, especially the kidney and liver. The...
- This federal Project Grant award in the amount of $1,428,186.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), to Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Massachusetts. The project aims to investigate the role of CYP4F enzymes in regulating N-acyl amino acid signaling in humans, which has implications for understanding the early...
- This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research focused on understanding the mechanisms that regulate lipid flux in cells and animals, and how crosstalk between gut immune cells and the absorptive epithelium impacts metabolic disease. The $761,399 award, effective September 1, 2025 through June 30, 2030, will...
- This Project Grant award of $1,170,271 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research program) aims to investigate the mechanisms by which the X-box binding protein 1 (XBP1) pathway regulates bile acid metabolism during cholestatic liver disorders. The central hypothesis is that hepatic XBP1 activation reduces bile acid synthesis and regulates bile acid metabolism by transcriptionally...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) is providing $179,000.00 to St. John's University in New York to investigate the physiological role of 16α-hydroxylated bile acids in regulating energy intake and hepatic lipid metabolism. The project aims to determine how 16α-hydroxylated bile acids affect these metabolic processes and enhance the synthesis of bioactive lipids. The research will utilize cell cultures, metabolic assays, reporter assays, and genetically modified mouse models to elucidate the specific targeting and mechanisms of 16α-hydroxylated bile acids. The project period runs from September 1, 2025 to July 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $179.0k | 8/11/25 |