This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $492,409 to support research aimed at understanding the role of the creatine pathway in regulating intestinal goblet cell development and its impact on inflammatory bowel disease (IBD). The key objectives of this 5-year project are to evaluate how creatine deficiency affects...
This federal Project Grant award of $673,379 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports the development of a novel synthetic biology-based oral immunotherapy for treating ulcerative colitis. The goal is to develop "R-3750", an engineered Lactococcus lactis strain that expresses the anti-inflammatory surface layer protein A (SLPA), as a...
This $498,064 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The Benaroya Research Institute at Virginia Mason, a non-profit research organization, will conduct research to identify genetic variants that drive the pathogenic activity of T cells implicated in inflammatory bowel diseases (IBDs). The research will utilize massively parallel...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $2,236,687 to support research on the regulation of intestinal immunity and repair by integrins. The primary awardee, Benaroya Research Institute at Virginia Mason, will conduct studies to investigate the role of the integrin αvβ6 in activating transforming growth factor-beta (TGF-β) to...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is designed to elucidate the role of deep crypt secretory (DCS) cells in colonic inflammation and tissue repair. The $551,112 award, which runs from September 2024 to June 2029, will support research at Children's Hospital Los Angeles to: 1) test whether impaired DCS cell responses...
This federal Project Grant award of $630,815, granted by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 "Diabetes, Digestive, and Kidney Diseases Extramural Research" program, supports research to investigate the role of the MTG16 transcriptional co-repressor in regulating colon cell identity and regenerative processes. The key products and services to be delivered under this 4-year award include: Defining the contributions of...
This $1,078,081 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports the development of a novel class of small molecule antagonists to the retinoic acid receptor-alpha (RAR) that can regulate gut homing of activated T cells. The research, conducted by Orphagen Pharmaceuticals, Inc., aims to advance a promising therapeutic approach for...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $664,163 to the Icahn School of Medicine at Mount Sinai to investigate the role of CD39 expression on gamma delta intraepithelial lymphocytes (gd IELs) in maintaining intestinal mucosal homeostasis and preventing inflammatory bowel disease (IBD) relapse. The research aims to elucidate...
This $202,728 federal Project Grant awarded by the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program funds a collaborative research project to develop a theragnostic (therapeutic and diagnostic) system for inflammatory bowel diseases (IBD). The project aims to integrate data science, synthetic biology, and additive manufacturing to model the complex interplay of host, microbial, and environmental factors in IBD, and develop an engineered...
This $919,404 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports the development of QR401 - an oral nanomedicine technology by Qrono, Inc. that targets antigen-presenting cells to restore immune tolerance and alleviate inflammatory bowel disease (IBD). The project aims to characterize and prepare enteric-coated nanoparticles containing the...