Project Grant K01DK141963

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) has awarded a 5-year, $156,982 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Johns Hopkins University. The grant, titled "Improving Diabetes Prediction Using Clinical Factors, Proteomic Biomarkers, and Polygenic Risk Scores," will support Dr. Mary Rooney, an Assistant Research Professor at the Johns Hopkins Bloomberg School of Public Health, in developing a more precise approach to diabetes risk stratification. The key objectives are to: 1) harmonize datasets and pool participant-level data from 13 epidemiologic cohorts; 2) refine prediabetes definitions by integrating clinical factors, novel proteomic biomarkers, and genetic susceptibility; and 3) quantify the associations of these risk stratification factors with the risk of diabetes complications. This research aims to inform clinical and public health strategies for screening and primary prevention of diabetes and its complications.