Project Grant K01DK140634
Award Date
8/1/25
Completion Date
7/31/30
Dollars Obligated
$149K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Pensilvania, EE. UU.
Similar Awards
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is funding research to develop a therapeutic approach using dicarboxylic acids (DCAs) to prevent and treat acute kidney injury (AKI) and limit progression to chronic kidney disease (CKD). The $645,599 award to the University of Pittsburgh is supporting preclinical studies in animal models...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $115,500 to Wayne State University to conduct research on the molecular mechanisms by which high-salt diets regulate the activity of the sodium-potassium-chloride cotransporter (NKCC2) in the thick ascending limb of the kidney. The research aims to identify novel E3 ubiquitin...
This federal Project Grant award of $293,128 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research will support research by The Johns Hopkins University to uncover the role of the G-protein coupled receptor GPR39 in kidney physiology. The research aims to examine the mechanisms by which GPR39 activation influences water reabsorption in the kidney and determine the physiologic function of...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $168,886.00 to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research titled "Elucidating the Role of NAD+ and PARylation in Nephron Endowment." The award aims to study how maternal availability of nicotinamide adenine dinucleotide...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is funding research to investigate intracellular cholesterol biosynthesis as a regulator of polycystic kidney disease (PKD) progression. The $504,621 award to the University of Texas Southwestern Medical Center will support a 5-year research project to: 1) determine if reducing...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $2,202,378 to the Icahn School of Medicine at Mount Sinai to conduct research on the protective role of the KLF2 gene in diabetic kidney disease (DKD). The key goals are to determine how KLF2 is regulated in diabetic conditions, how it protects against glomerular endothelial...
This $199,990 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at The Ohio State University to investigate the role of the transcriptional corepressor CTBP2 as a metabolic sensor in acute kidney injury (AKI). The key objectives are to: 1) examine how acetylation regulates the nuclear localization and activation...
This $142,902 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to uncover the mechanism by which the regulatory GTPase ARL13B drives polycystic kidney disease (PKD) pathogenesis. The research, led by Dr. Van Sciver at Emory University, will biochemically and genetically dissect ARL13B's interaction with three effector proteins - CDK1, ARL3,...
This $820,119 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research focused on elucidating the mechanobiological functions of novel cytoskeletal structures in podocytes to reveal new therapeutic opportunities for kidney glomerular diseases. The primary research aims to better understand the mechanisms underlying podocyte homeostasis,...
The University of Pittsburgh received a $198,750 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to develop a rapid, quantitative platform using yeast to classify how approximately 70 identified mutations in the polycystin-1 (PC1) protein disrupt channel activity with PC2. This research aims to provide new reagents and assays to the scientific and PKD (polycystic kidney disease) community to study the molecular defects of PC1 mutants. The...