Project Grant K01DC022958
- The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $650,049 Project Grant under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to Duke University. The 5-year grant, commencing on May 1, 2025, will fund research to investigate the structural determinants of odorant receptor (OR) activation and the corresponding neural signaling in the mouse olfactory system. The project aims to understand how external odor signals are...
- Federal Project Grant Award Summary The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $619,942 Project Grant to The Trustees of Columbia University in the City of New York, Health Sciences Division, effective September 1, 2025, through August 31, 2030. Under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), this award supports fundamental research investigating solid phase transitions as a mechanism facilitating olfactory...
- Federal Project Grant Award Summary Cold Spring Harbor Laboratory received a $432,000 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), effective August 1, 2025 through July 31, 2030. The award funds research into the mechanisms of odorant receptor map formation in mice, with the primary deliverable being a comprehensive mapping and characterization of all...
- Grant Award Summary The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $258,550 Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) on June 8, 2025, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The research initiative, "Disentangling the Roles of Endoplasmic Reticulum Stress and Activity in the Peripheral Olfactory Circuit," will be conducted through...
- Federal Project Grant Award Summary New York University School of Medicine received a $139,617 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), effective May 1, 2026, through April 30, 2028. This award supports fundamental neuroscience research investigating the neural circuits and computational mechanisms underlying olfactory perception, which falls...
- Federal Project Grant Award Summary The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $656,479 Project Grant to the Monell Chemical Senses Center effective May 1, 2026, through April 30, 2031, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The research project, titled "Influenza Virus Induced Neuroinflammation in the Olfactory Sensory System and Long-Term Anosmia," will investigate the mechanisms underlying...
- Federal Project Grant Award Summary Cold Spring Harbor Laboratory received a $2.77 million Project Grant from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), awarded on August 1, 2025, with a completion date of July 31, 2029. The award supports fundamental neuroscience research investigating how social odor cues modulate auditory perception and maternal behavior in mice, with...
- Federal Grant Award Summary Harvard Medical School, operating as the Office of Research Administration Division of President and Fellows of Harvard College, received a $688,796 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) on August 6, 2025. The award supports a five-year research initiative extending through July 31, 2030, focused on characterizing...
- Federal Grant Award Summary The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded The Morgridge Institute for Research, Inc. a $495,000 Project Grant effective August 1, 2025, through July 31, 2027, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). This award supports investigative research into the cellular mechanisms and molecular basis of mitral cell regeneration in the adult zebrafish olfactory bulb, utilizing a precision...
- Federal Project Grant Award Summary The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded $579,187 to the Monell Chemical Senses Center under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) on March 1, 2026, with a completion date of February 28, 2031. This project grant supports fundamental research on the molecular and neural mechanisms underlying food texture perception using Drosophila melanogaster (fruit fly) as a model...
Project Grant Award Summary The Beckman Research Institute of The City of Hope received a $122,742 project grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The award, effective May 1, 2026 through April 30, 2031, funds computational research to elucidate ligand selectivity mechanisms in olfactory receptors through advanced allosteric analysis. The research will utilize long-timescale molecular dynamics simulations and allosteric pathway analysis to investigate structural and dynamic properties of two specific olfactory receptors (OR51E2 and OR1A1), identifying critical residues and pathways involved in ligand binding and receptor activation. The project deliverables include novel insights into how lipid environments and extracellular factors modulate olfactory receptor activity, with the ultimate goal of developing innovative therapeutic strategies—including negative allosteric modulators and proteolysis targeting chimeras (PROTACs)—to address sensory disorders caused by disrupted olfactory receptor function. This research addresses a critical knowledge gap in understanding how approximately 400 human olfactory receptors distinguish among the vast array of odorants, and will inform therapeutic interventions for taste and smell disorders potentially caused by pharmaceutical agents.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $122.7k | 4/27/26 |