Project Grant K01DA065775
- The National Institute on Drug Abuse awarded The Medical University of South Carolina $602,327 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a randomized, placebo-controlled trial of varenicline as a treatment for cannabis use disorder. The trial will enroll participants balanced by sex and randomize them to receive varenicline or placebo, with all participants receiving standardized cognitive behavioral treatment targeting antecedents of...
- The National Institute on Drug Abuse awarded The Medical University of South Carolina $211,680 under NIDA's Drug Use and Addiction Research Programs (CFDA 93.279) on August 1, 2026. The recipient will conduct mixed-methods research characterizing hemp-derived alternative cannabinoid product use in natural settings. The project comprises two national, decentralized studies: an online survey and a six-month naturalistic ecological momentary assessment study. Research will assess alternative...
- The National Institute on Drug Abuse awarded the University of California, San Diego $1,468,376 under the Drug Use and Addiction Research Programs (CFDA 93.279) on July 15, 2026, to conduct a prospective study characterizing sex-specific cannabinoid and endocannabinoid biomarkers as predictors of neuropsychological, behavioral, and withdrawal outcomes during cannabis abstinence in emerging adults. The research will recruit 220 participants aged 18–25 (balanced by sex, 64 percent with heavy...
- The National Institute on Drug Abuse awarded Carnegie Mellon University $191,250 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate THC exposure and inhibitory circuit plasticity in the neocortex. The research examines acute and long-term effects of tetrahydrocannabinol (THC), the main psychoactive component of cannabis, on neocortical interneurons expressing the highest levels of cannabinoid receptors in the mammalian brain. The project will...
- The National Institute on Drug Abuse awarded The Johns Hopkins University $708,190 under the Drug Use and Addiction Research Programs (CFDA 93.279) on July 1, 2026, to conduct double-blind, placebo-controlled human laboratory studies examining the pharmacokinetic and pharmacodynamic effects of varying tetrahydrocannabinol (THC) and cannabidiol (CBD) ratios in cannabis edibles. Research Aim 1 will evaluate how different THC:CBD ratios—including 1:0, 1:1, 1:5, 1:10, 1:30, and 0:1—affect THC...
- The National Institute on Drug Abuse awarded The Medical University of South Carolina $211,680 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support research investigating neurobiological mechanisms underlying reward-cue associations and relapse-like behavior in substance use disorders. The project, NPAS4+ Neuronal Ensembles: Mechanisms of Reward-Cue Associations and Relapse-Like Behavior, examines how neuronal activity in the nucleus accumbens...
- The National Institute on Drug Abuse awarded Washington State University $420,750 on July 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the neurobiological substrates of cannabis-seeking behavior through preclinical research models. The funded research combines fiber photometry and wireless recording techniques to examine how dynamic neural activity and dopamine release in corticostriatal circuits—specifically the medial prefrontal cortex and nucleus...
- The National Institute on Drug Abuse awarded Duke University $731,879 on May 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the impact of cannabis use on the inflammasome in people with HIV compared to HIV-seronegative persons. The research leverages biospecimens from a cohort of clinically and neurologically phenotyped HIV-infected cannabis users and non-users to determine how recreational cannabis use modulates the NLRP3 inflammasome and its effects on...
- The National Institute on Drug Abuse awarded The Medical University of South Carolina $100,228 on January 14, 2027, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support research into the functional role of the thalamus in coordinating dorsolateral striatum encoding of habit learning. The research addresses how the paraventricular thalamus regulates the neural mechanisms underlying the transition from flexible, goal-directed behavior to automatic habitual behavior—a...
- The National Institute on Drug Abuse awarded the Research Foundation For Mental Hygiene, Inc. (operating through its New York State Psychiatric Institute division) $195,804 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279). The award funds a five-year research project examining how cannabis influences nicotine use among young and emerging adults (ages 18–35) who use electronic nicotine delivery systems. The study integrates human laboratory methods with...
The National Institute on Drug Abuse awarded The Medical University of South Carolina $207,792 on August 1, 2026, to examine sex differences in the endocannabinoid system and their contribution to differential THC-associated reward in individuals with cannabis use disorder. The research employs a multi-modal human laboratory paradigm involving 134 adults with cannabis use disorder. Participants will undergo pharmacogenetic screening to identify endocannabinoid-related genetic polymorphisms in CNR1 and FAAH genes associated with increased endocannabinoid expression. A matched sub-sample of 20 participants per sex will participate in two human laboratory dosing sessions receiving either 40 milligrams of oral THC or placebo. At each session, participants will complete subjective assessments of acute drug reward, proton magnetic resonance spectroscopy imaging of the nucleus accumbens to measure reward-processing brain activity, and repeated blood draws to assess peripheral endocannabinoid tone. The project synthesizes pharmacological, genetic, and neuroimaging approaches to determine whether sex differences in endocannabinoid system expression and function mediate differential THC reward susceptibility, with potential implications for individualized cannabis use disorder treatment. Work is performed in Charleston, South Carolina. The period of performance runs through July 31, 2031. This award is made under the Drug Use and Addiction Research Programs (CFDA 93.279), which supports basic, clinical, translational, and implementation research on substance use prevention, diagnosis, and treatment.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $207.8k | 7/22/26 |