Project Grant K01AR085194
- This federal Project Grant award of $735,372.00, made by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research at Brigham & Women's Hospital Inc. to investigate the regulatory mechanisms controlling the expression of chemokine receptors on T cells that drive their migration to inflamed tissues in chronic autoimmune conditions. The research aims to use CRISPR...
- This Project Grant award of $139,895.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research into the link between inflammatory arthritis and the development of cardiovascular disease. The key objectives are to investigate whether "trained immunity" - the phenomenon where innate immune cells become reprogrammed to respond more efficiently to a...
- This five-year Project Grant award for $382,537, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to determine the pathogenic roles of granzyme K-expressing CD8 T cells in the synovial tissue of patients with rheumatoid arthritis. The primary objectives are to investigate whether these cells are antigen-specific and activated, or instead...
- This federal Project Grant award, in the amount of $177,000.00, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports research focused on understanding the genetic pathways that direct chondrocyte (cartilage cell) maturation and skeletal growth, with the goal of identifying novel modulators that could inform the development of treatments for...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will provide $147,917 to Brigham & Women's Hospital Inc. over a 5-year period from January 1, 2025 to December 31, 2029. The key objectives of this award are to: 1) Recruit rheumatoid arthritis (RA) patients and assess their cardiovascular disease risk using high-sensitivity cardiac troponin...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $212,574 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846) to Seattle Children's Hospital, doing business as Seattle Children's Research Institute. The grant will support Dr. Shaun Jackson, an established researcher in pediatric autoimmunity, to expand his mentorship of junior scientists engaged in patient-oriented research at the...
- This $529,682 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research at the Lankenau Institute for Medical Research to define the cellular and molecular mechanisms of indoleamine-2,3-dioxygenase (IDO2) that drive autoimmune versus protective immune responses. The research aims to better understand IDO2's enzymatic and non-enzymatic...
- This Project Grant award, totaling $147,486 and provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), is part of the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports research to investigate the impact of Toll-like receptor (TLR) signaling on osteoclast-mediated bone remodeling and inflammation in osteoarthritis. The project aims to elucidate the mechanisms by which TLR signaling in osteoclasts modulates the...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $170,101 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to Brigham & Women's Hospital, a subsidiary of Partners Healthcare System, for a project titled "Dissecting the Spatial Heterogeneity of Synovial Inflammation in Rheumatoid Arthritis". The project aims to systematically characterize the spatial heterogeneity of synovial inflammation in rheumatoid...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $529,616 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to Brigham & Women's Hospital Inc. in Boston, Massachusetts. The grant, with a period of performance from June 1, 2025 to May 31, 2030, will fund research to define the role of Notch signaling in driving a fibrogenic program that contributes to treatment failure in rheumatoid arthritis (RA)....
This K01 career development award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS, CFDA 93.846) provides $122,563 to Dr. Taehyeung Kim at Boston Children's Hospital to conduct research on how non-coding genetic variants modulate regulatory T cells (Tregs) in autoimmune diseases like rheumatoid arthritis. The project aims to investigate how a specific variant affects Treg abundance and uncover novel genetic pathways regulating Treg immunity, with the goal of identifying potential therapeutic targets. The award will support Dr. Kim's advanced research training, protected time, and mentorship needed to establish himself as an independent investigator specialized in functional genomics of immune cells in autoimmunity.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $122.6k | 8/18/25 |