Project Grant K01AG090892
Award Date
6/1/25
Completion Date
3/31/30
Dollars Obligated
$127K
Federal Agency
National Institute on Aging
Awardee
Yale Univ (FL6GV84CKN57)
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Connecticut, USA
Similar Awards
This Project Grant from the National Institutes of Health National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $5,006,006 to Yale University to support multimodal imaging research aimed at better understanding Alzheimer's disease pathogenesis and treatment response. Specifically, the award will fund research leveraging positron emission tomography, wide-field calcium imaging, and functional magnetic resonance imaging to map changes in excitatory and inhibitory...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to examine the associations between early and later-life stress on later-life cognition and plasma biomarkers of Alzheimer's disease and related dementias (ADRD). The total award amount is $195,896.00 over a period from October 26, 2024 to April 30, 2026. The research will be conducted by Wake Forest University Health Sciences, a leading academic medical center and established...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $461,146 to Yale University to investigate the dysregulation of cortical astrocytes, a key cell type involved in inflammatory responses and synaptic function, in Alzheimer's disease (AD) models. The research aims to longitudinally track changes in astrocytic and neuromodulatory signaling across the cortex in awake, behaving animals using novel imaging approaches. The goal is to elucidate the...
This federal Project Grant award for $461,313, provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports research to investigate the role of the protein CSPα in regulating synaptic autophagy and its implications for neurodegenerative diseases. The research aims to characterize synaptic vesicles, autophagosomes, and related proteins in wild-type, CSPα knockout, and CLN4 (a neurodegenerative disease) models using techniques such as electron microscopy,...
The Washington University in St. Louis, Office of Sponsored Research Services Division, received a $2,133,060 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866). The grant will support research to investigate the sex-dependent effects of stress on the accumulation of amyloid-beta (Aβ) and tau proteins, which are hallmarks of Alzheimer's disease pathology. The study aims to elucidate the signaling pathways that mediate the differential...
The National Institute on Aging (CFDA 93.866 Aging Research) awarded a $148,568 Project Grant to Brandeis University to conduct research on the neurobiological mechanisms underlying daily life activity participation in older adults and its linkages to Alzheimer's disease pathology. The proposed research will use a multilevel, multimodal framework to study the behavioral and neurobiological mechanisms of age-related shifts in motivation to perform cognitively effortful activities, and directly...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $239,122 to Yale University to leverage computational and experimental approaches to study the impact of aging processes and Alzheimer's disease (AD) risk variants on chromatin accessibility and gene expression in human neural and glial cells. The 2-year project aims to: 1) develop a cell-type specific regulatory network model for normal brain aging and AD brain aging, and 2) generate...
This $837,500 Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) supports research to characterize the properties and performance of the PET radiotracer [18F]3F4AP for detecting and quantifying demyelination and cerebral perfusion in Alzheimer's disease, mild cognitive impairment, and cognitively normal individuals. The project aims to conduct the first full pharmacokinetic evaluation of [18F]3F4AP in human subjects and validate...
This National Institute on Aging (NIA) Project Grant award under CFDA Program 93.866 "Aging Research" provides $254,250 to New York University (NYU) School of Medicine to develop a biologically relevant multi-scale model of brain aging using advanced diffusion MRI (dMRI) techniques. The project aims to create a brain microstructure age framework by generating brain charts of quantitative dMRI and mesoscopic MRI (mesoMRI) markers across the lifespan. It will evaluate the effects of...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $459,250 to The General Hospital Corporation (dba Massachusetts General Hospital) to investigate the impact of stress and resilience on the progression of Alzheimer's disease pathology and cognitive function. The 2-year project aims to leverage longitudinal data from established research cohorts to determine the temporal associations between stress, resilience, amyloid and tau pathology,...