Project Grant K01AG090753
- This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) is supporting the development of a "Multimodal, Multiscale and Multistage Systems Biology (M3SB) Infrastructure for Precision Medicine in Alzheimer's Disease and Longevity". The $802,034 award aims to conduct multi-modal analyses of genetics, multi-omics data, cross-species protein interactome networks, and human brain-specific functional genomic data to identify...
- This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,041,438 to develop new computational tools and biomarkers for Alzheimer's disease. The University of Miami will aggregate and analyze DNA methylation datasets to identify age-associated epigenetic changes related to aging and Alzheimer's progression. Researchers will create a searchable web interface to disseminate findings on the role of DNA...
- This federal Project Grant award of $2,631,670 from the National Institute on Aging (CFDA 93.866 Aging Research) supports a research initiative at The Washington University to investigate age-related deficits in episodic memory. The project aims to determine how aging distinctly affects the content and structure of memory representations, and how this relates to dysfunction in different brain networks based on susceptibility to Alzheimer's disease pathology. The research will utilize plasma...
- This Project Grant award, funded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), provides $420,750 to Washington State University to investigate the complex interactions between aging, transcriptional processing, protein aggregation, sleep disturbance, and cognitive decline in an Alzheimer's disease rat model. The researchers will leverage innovative techniques, such as the use of single-chain variable fragments to evaluate protein oligomerization,...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to gain a mechanistic understanding of the role of cellular senescence in the pathogenesis of Alzheimer's disease (AD). The $460,625 grant will fund research at the University of Massachusetts Medical School to dissect the separate P53/P21 and P16 senescence pathways and their functional consequences in AD using human induced pluripotent stem cell-based models. The 2-year project will produce...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $848,286 to the University of South Florida to conduct research on the role of N6-methyladenosine (m6A) RNA modifications in Alzheimer's disease (AD). The key objectives are to: 1) Create a high-resolution map of m6A sites in the brains of older adults, 2) Identify specific m6A alterations associated with AD and its clinical/pathological features, and 3) Elucidate how m6A dysregulation may...
- This Project Grant award of $1,851,569 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research investigating the relationship between early brain development and later neurodegeneration associated with Alzheimer's disease (AD). The research aims to test two key hypotheses: 1) brain regions with high plasticity in early life are more susceptible to pathological changes later in life, and 2) the detrimental impact of social determinants of health (e.g., low...
- This federal Project Grant award for $528,876, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research to investigate the cis- and trans-genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease (AD) and AD-related dementias (ADRD). The key goals of the project are to: Estimate genome-wide cis- and trans-acting quantitative trait loci (QTLs) effects for transcriptome-wide genes and proteome-wide proteins across 4 brain...
- The National Institute on Aging awarded a Project Grant of $455,274 to The Johns Hopkins University on May 15, 2025 under the Aging Research Federal Grant Program (CFDA 93.866). The objective of this project is to develop and apply statistical methods to improve scientific inferences in Alzheimer's disease (AD) research when using cross-sectional or longitudinal study designs. The proposed approaches aim to handle age-specific prevalent cases in case-control studies, develop regression methods...
- This federal Project Grant award of $307,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct a single, highly powered study to identify memory processes that are most sensitive to the asymptomatic, preclinical stage of Alzheimer's disease (AD) pathology. The study combines a continuous report item-location associative memory task with advanced behavioral and neural modeling to estimate subtle changes in memory precision that may differentiate healthy...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a study to compare state-of-the-art biological age clocks across epigenetic, proteomic, and neuroimaging modalities. The goal is to identify complementary signatures of biological aging, disease progression, and resilience in sporadic late onset Alzheimer's disease (SLOAD) and autosomal dominant Alzheimer's disease (ADAD). The $128,373 award, effective August 15, 2025 through May 31, 2030, will support research conducted by the Washington University in Missouri. The study will leverage available longitudinal human datasets to test whether epigenetic, proteomic, and brain-predicted age clocks represent unique signals of aging processes in these Alzheimer's disease subtypes. Researchers will examine how proteomic age may mediate the relationship between epigenetic and brain-predicted age clocks. The findings could elucidate complementary biomarkers of Alzheimer's risk and resilience.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $128.4k | 8/8/25 |